|
| USC Trojans vs Temple Owls | Saturday, November 13, 2021 | 6:30 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Clemson Tigers vs Temple Owls | Thursday, November 18, 2021 | 4:30 PM EST | TD Arena in Charleston, SC | ESPN2 |
| Delaware Blue Hens vs Temple Owls | Sunday, November 28, 2021 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| La Salle Explorers vs Temple Owls | Thursday, December 2, 2021 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs Vanderbilt Commodores | Tuesday, December 7, 2021 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Temple Owls vs Saint Joseph’s Hawks | Saturday, December 11, 2021 | 7:00 PM EST | Michael J. Hagan ’85 Arena in Philadelphia, PA | ESPN+ |
| UCF Knights vs Temple Owls | Thursday, December 16, 2021 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN2 |
| Drexel Dragons vs Temple Owls | Saturday, December 18, 2021 | 2:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs Villanova Wildcats | Thursday, December 30, 2021 | 9:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Houston Cougars vs Temple Owls | Sunday, January 2, 2022 | 5:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs UCF Knights | Wednesday, January 5, 2022 | 7:00 PM EST | Addition Financial Arena in Orlando, FL | ESPN+ |
| East Carolina Pirates vs Temple Owls | Saturday, January 8, 2022 | 2:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs Tulsa Golden Hurricane | Thursday, January 13, 2022 | 7:00 PM EST | Donald W. Reynolds Center in Tulsa, OK | ESPNU |
| Wichita State Shockers vs Temple Owls | Thursday, January 20, 2022 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs USF Bulls | Saturday, January 22, 2022 | 12:00 PM EST | Yuengling Center in Tampa, FL | ESPNU |
| Cincinnati Bearcats vs Temple Owls | Wednesday, January 26, 2022 | 7:00 PM EST | Liacouras Center in Philadelphia, PA | ESPNU |
| Tulsa Golden Hurricane vs Temple Owls | Saturday, February 5, 2022 | 2:00 PM EST | Liacouras Center in Philadelphia, PA | ESPN+ |
| Temple Owls vs Tulane Green Wave | Saturday, February 12, 2022 | 7:00 PM EST | Avron B. Fogelman Arena in the Devlin Fieldhouse in New Orleans, LA | ESPN+ |
| Temple Owls vs Cincinnati Bearcats | Sunday, February 20, 2022 | 2:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Temple Owls vs Memphis Tigers | Friday, February 25, 2022 | 7:00 PM EST | FedExForum in Memphis, TN | ESPN2 |
| Temple Owls vs Houston Cougars | Friday, March 4, 2022 | 7:00 PM EST | Fertitta Center in Houston, TX | ESPN+ |
