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| Tennessee Tech Golden Eagles vs Memphis Tigers | Tuesday, November 9, 2021 | 6:30 PM EST | FedExForum in Memphis, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Chattanooga Mocs | Tuesday, November 16, 2021 | 6:30 PM EST | McKenzie Arena in Chattanooga, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs UNC Asheville Bulldogs | Thursday, November 18, 2021 | 6:30 PM EST | Kimmel Arena in Asheville, NC | ESPN+ |
| Lipscomb Bisons vs Tennessee Tech Golden Eagles | Tuesday, November 23, 2021 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Tennessee Volunteers | Friday, November 26, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN+ |
| Chattanooga Mocs vs Tennessee Tech Golden Eagles | Tuesday, November 30, 2021 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Western Carolina Catamounts | Wednesday, December 8, 2021 | 7:00 PM EST | Ramsey Regional Activity Center in Cullowhee, NC | ESPN+ |
| Troy Trojans vs Tennessee Tech Golden Eagles | Saturday, December 11, 2021 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Wright State Raiders | Saturday, December 18, 2021 | 7:00 PM EST | Nutter Center in Dayton, OH | ESPN+ |
| Tennessee Tech Golden Eagles vs Cincinnati Bearcats | Tuesday, December 21, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Tennessee Tech Golden Eagles vs Tennessee State Tigers | Friday, December 31, 2021 | 8:30 PM EST | Gentry Center in Nashville, TN | ESPN+ |
| Morehead State Eagles vs Tennessee Tech Golden Eagles | Thursday, January 6, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Eastern Illinois Panthers vs Tennessee Tech Golden Eagles | Saturday, January 8, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs SE Missouri State Redhawks | Thursday, January 13, 2022 | 7:00 PM EST | Show Me Center in Cape Girardeau, MO | ESPN+ |
| Tennessee Tech Golden Eagles vs UT Martin Skyhawks | Saturday, January 15, 2022 | 3:30 PM EST | Skyhawk Arena in Martin, TN | ESPN+ |
| SIU Edwardsville Cougars vs Tennessee Tech Golden Eagles | Thursday, January 20, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Belmont Bruins | Saturday, January 22, 2022 | 7:00 PM EST | Curb Event Center Arena in Nashville, TN | ESPN+ |
| Murray State Racers vs Tennessee Tech Golden Eagles | Thursday, January 27, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Morehead State Eagles | Thursday, February 3, 2022 | 7:00 PM EST | Ellis T. Johnson Arena in Morehead, KY | ESPN+ |
| Belmont Bruins vs Tennessee Tech Golden Eagles | Saturday, February 5, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs SIU Edwardsville Cougars | Saturday, February 12, 2022 | 3:30 PM EST | First Community Arena at the Vadalabene Center in Edwardsville, IL | ESPN+ |
| SE Missouri State Redhawks vs Tennessee Tech Golden Eagles | Thursday, February 17, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| Tennessee Tech Golden Eagles vs Austin Peay Governors | Saturday, February 19, 2022 | 7:00 PM EST | Winfield Dunn Center in Clarksville, TN | ESPN+ |
| Tennessee State Tigers vs Tennessee Tech Golden Eagles | Friday, February 25, 2022 | 8:30 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
| UT Martin Skyhawks vs Tennessee Tech Golden Eagles | Saturday, February 26, 2022 | 7:00 PM EST | Hooper Eblen Center in Cookeville, TN | ESPN+ |
