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| UT Martin Skyhawks vs Tennessee Volunteers | Wednesday, November 10, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Tennessee Tech Golden Eagles vs Tennessee Volunteers | Friday, November 26, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN+ |
| Presbyterian Blue Hose vs Tennessee Volunteers | Wednesday, December 1, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Texas Tech Red Raiders vs Tennessee Volunteers | Wednesday, December 8, 2021 | 7:00 PM EST | Madison Square Garden in New York, NY | ESPN |
| UNC Greensboro Spartans vs Tennessee Volunteers | Saturday, December 11, 2021 | 4:30 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| USC Upstate Spartans vs Tennessee Volunteers | Tuesday, December 14, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN+ |
| Tennessee Volunteers vs Memphis Tigers | Saturday, December 18, 2021 | 12:00 PM EST | Bridgestone Arena in Nashville, TN | ESPN+ |
| Arizona Wildcats vs Tennessee Volunteers | Thursday, December 23, 2021 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN2 |
| Tennessee Volunteers vs Alabama Crimson Tide | Thursday, December 30, 2021 | 9:00 PM EST | Coleman Coliseum in Tuscaloosa, AL | ESPN2 |
| Ole Miss Rebels vs Tennessee Volunteers | Thursday, January 6, 2022 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Tennessee Volunteers vs LSU Tigers | Saturday, January 8, 2022 | 6:00 PM EST | Pete Maravich Assembly Center in Baton Rouge, LA | ESPN+ |
| South Carolina Gamecocks vs Tennessee Volunteers | Tuesday, January 11, 2022 | 6:30 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Tennessee Volunteers vs Kentucky Wildcats | Saturday, January 15, 2022 | 7:00 PM EST | Rupp Arena in Lexington, KY | ESPN |
| Tennessee Volunteers vs Vanderbilt Commodores | Wednesday, January 19, 2022 | 9:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| LSU Tigers vs Tennessee Volunteers | Saturday, January 22, 2022 | 6:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN |
| Florida Gators vs Tennessee Volunteers | Wednesday, January 26, 2022 | 6:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN2 |
| Texas A&M Aggies vs Tennessee Volunteers | Wednesday, February 2, 2022 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Tennessee Volunteers vs South Carolina Gamecocks | Saturday, February 5, 2022 | 7:00 PM EST | Colonial Life Arena in Columbia, SC | ESPN+ |
| Tennessee Volunteers vs Mississippi State Bulldogs | Thursday, February 10, 2022 | 9:00 PM EST | Humphrey Coliseum in Starkville, MS | ESPN+ |
| Vanderbilt Commodores vs Tennessee Volunteers | Saturday, February 12, 2022 | 6:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Kentucky Wildcats vs Tennessee Volunteers | Wednesday, February 16, 2022 | 9:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN+ |
| Tennessee Volunteers vs Arkansas Razorbacks | Saturday, February 19, 2022 | 7:00 PM EST | Bud Walton Arena in Fayetteville, AR | ESPN+ |
| Tennessee Volunteers vs Missouri Tigers | Wednesday, February 23, 2022 | 7:00 PM EST | Mizzou Arena in Columbia, MO | SEC Network |
| Auburn Tigers vs Tennessee Volunteers | Saturday, February 26, 2022 | 7:00 PM EST | Thompson-Boling Arena in Knoxville, TN | ESPN+ |
| Tennessee Volunteers vs Georgia Bulldogs | Tuesday, March 1, 2022 | 6:30 PM EST | Stegeman Coliseum in Athens, GA | SEC Network |
