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| Texas Southern Tigers vs Oregon Ducks | Wednesday, November 10, 2021 | 7:00 PM EST | Matthew Knight Arena in Eugene, OR | PAC12 |
| Texas Southern Tigers vs St. Mary’s Gaels | Saturday, November 13, 2021 | 7:00 PM EST | University Credit Union Pavilion in Moraga, CA | ESPN+ |
| Texas Southern Tigers vs Washington Huskies | Tuesday, November 16, 2021 | 9:00 PM EST | Alaska Airlines Arena in Seattle, WA | PAC12 |
| Texas Southern Tigers vs NC State Wolfpack | Sunday, November 21, 2021 | 7:00 PM EST | PNC Arena in Raleigh, NC | ESPN+ |
| Texas Southern Tigers vs BYU Cougars | Thursday, November 25, 2021 | 9:00 PM EST | Marriott Center in Provo, UT | ESPN+ |
| Texas Southern Tigers vs Louisiana Tech Bulldogs | Wednesday, December 1, 2021 | 7:00 PM EST | Thomas Assembly Center in Ruston, LA | ESPN+ |
| Texas Southern Tigers vs Florida Gators | Monday, December 6, 2021 | 7:00 PM EST | Exactech Arena at Stephen C. O’Connell Center in Gainesville, FL | ESPN+ |
| Texas Southern Tigers vs UTRGV Vaqueros | Wednesday, December 15, 2021 | 8:30 PM EST | UTRGV Fieldhouse in Edinburg, TX | ESPN+ |
| Texas Southern Tigers vs Cincinnati Bearcats | Saturday, December 18, 2021 | 7:00 PM EST | Fifth Third Arena in Cincinnati, OH | ESPN+ |
| Texas Southern Tigers vs TCU Horned Frogs | Wednesday, December 29, 2021 | 4:00 PM EST | Ed and Rae Schollmaier Arena in Fort Worth, TX | ESPN+ |
| Texas Southern Tigers vs Southern Jaguars | Tuesday, January 4, 2022 | 8:30 PM EST | F. G. Clark Activity Center in Baton Rouge, LA | ESPN+ |
| Texas Southern Tigers vs Grambling Tigers | Thursday, January 6, 2022 | 8:30 PM EST | Fredrick C. Hobdy Assembly Center in Grambling, LA | ESPN+ |
| Arkansas-Pine Bluff Golden Lions vs Texas Southern Tigers | Sunday, January 9, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| MVSU Delta Devils vs Texas Southern Tigers | Tuesday, January 11, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Texas Southern Tigers vs Alcorn State Braves | Saturday, January 15, 2022 | 7:00 PM EST | Davey L. Whitney Complex in Lorman, MS | ESPN+ |
| Texas Southern Tigers vs Jackson State Tigers | Tuesday, January 18, 2022 | 7:30 PM EST | Lee E. Williams Athletic and Assembly Center in Jackson, MS | ESPN+ |
| Alabama A&M Bulldogs vs Texas Southern Tigers | Sunday, January 23, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Alabama State Hornets vs Texas Southern Tigers | Tuesday, January 25, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Texas Southern Tigers vs Florida A&M Rattlers | Saturday, February 5, 2022 | 7:00 PM EST | Al Lawson Center in Tallahassee, FL | ESPN+ |
| Texas Southern Tigers vs Bethune-Cookman Wildcats | Monday, February 7, 2022 | 7:00 PM EST | Moore Gymnasium (Daytona Beach, FL) in Daytona Beach, FL | ESPN+ |
| Grambling Tigers vs Texas Southern Tigers | Sunday, February 13, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Southern Jaguars vs Texas Southern Tigers | Tuesday, February 15, 2022 | 8:30 PM EST | H&PE Arena in Houston, TX | ESPN+ |
| Texas Southern Tigers vs MVSU Delta Devils | Saturday, February 19, 2022 | 7:00 PM EST | Robert W. Harrison HPER Complex in Itta Bena, MS | ESPN+ |
| Texas Southern Tigers vs Arkansas-Pine Bluff Golden Lions | Monday, February 21, 2022 | 7:00 PM EST | H. O. Clemmons Arena in Pine Bluff, AR | ESPN+ |
| Jackson State Tigers vs Texas Southern Tigers | Sunday, February 27, 2022 | 8:00 PM EST | H&PE Arena in Houston, TX | ESPN+ |
