| North Florida Ospreys vs Texas Tech Red Raiders | Tuesday, November 9, 2021 | 4:30 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Grambling Tigers vs Texas Tech Red Raiders | Thursday, November 11, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Grambling Tigers vs Texas Tech Red Raiders | Friday, November 12, 2021 | 6:30 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Prairie View A&M Panthers vs Texas Tech Red Raiders | Monday, November 15, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Omaha Mavericks vs Texas Tech Red Raiders | Tuesday, November 23, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Lamar Cardinals vs Texas Tech Red Raiders | Saturday, November 27, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Texas Tech Red Raiders vs Providence Friars | Thursday, December 2, 2021 | 8:30 PM EST | Dunkin Donuts Center in Providence, RI | FS1 |
| Texas Tech Red Raiders vs Tennessee Volunteers | Wednesday, December 8, 2021 | 7:00 PM EST | Madison Square Garden in New York, NY | ESPN |
| Arkansas State Red Wolves vs Texas Tech Red Raiders | Tuesday, December 14, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Gonzaga Bulldogs vs Texas Tech Red Raiders | Saturday, December 18, 2021 | 1:00 PM EST | Footprint Center in Phoenix, AZ | ESPN+ |
| Eastern Washington Eagles vs Texas Tech Red Raiders | Wednesday, December 22, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Alabama State Hornets vs Texas Tech Red Raiders | Tuesday, December 28, 2021 | 7:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Texas Tech Red Raiders vs Iowa State Cyclones | Thursday, January 6, 2022 | 9:00 PM EST | James H. Hilton Coliseum in Ames, IA | ESPNU |
| Kansas Jayhawks vs Texas Tech Red Raiders | Saturday, January 8, 2022 | 4:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN2 |
| Texas Tech Red Raiders vs Baylor Bears | Wednesday, January 12, 2022 | 7:00 PM EST | Ferrell Center in Waco, TX | ESPN+ |
| Texas Tech Red Raiders vs Kansas State Wildcats | Saturday, January 15, 2022 | 7:00 PM EST | Bramlage Coliseum in Manhattan, KS | ESPNU |
| Iowa State Cyclones vs Texas Tech Red Raiders | Wednesday, January 19, 2022 | 9:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPNU |
| West Virginia Mountaineers vs Texas Tech Red Raiders | Saturday, January 22, 2022 | 12:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Texas Tech Red Raiders vs Kansas Jayhawks | Tuesday, January 25, 2022 | 9:00 PM EST | Allen Fieldhouse in Lawrence, KS | ESPN |
| Texas Longhorns vs Texas Tech Red Raiders | Wednesday, February 2, 2022 | 9:00 PM EST | United Supermarkets Arena in Lubbock, TX | ESPN+ |
| Texas Tech Red Raiders vs West Virginia Mountaineers | Saturday, February 5, 2022 | 7:00 PM EST | WVU Coliseum in Morgantown, WV | ESPN+ |
| Texas Tech Red Raiders vs Oklahoma Sooners | Thursday, February 10, 2022 | 9:00 PM EST | Lloyd Noble Center in Norman, OK | ESPN+ |
| TCU Horned Frogs vs Texas Tech Red Raiders | Saturday, February 12, 2022 | 4:00 PM EST | United Supermarkets Arena in Lubbock, TX | BIG12|ESPN+ |
| Texas Tech Red Raiders vs Texas Longhorns | Saturday, February 19, 2022 | 12:30 PM EST | Frank Erwin Center in Austin, TX | ABC |
| Oklahoma Sooners vs Texas Tech Red Raiders | Wednesday, February 23, 2022 | 8:00 PM EST | United Supermarkets Arena in Lubbock, TX | BIG12|ESPN+ |
| Texas Tech Red Raiders vs TCU Horned Frogs | Saturday, February 26, 2022 | 6:00 PM EST | Ed and Rae Schollmaier Arena in Fort Worth, TX | ESPN+ |
