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| UIC Flames vs Dayton Flyers | Tuesday, November 9, 2021 | 4:00 PM EST | UD Arena in Dayton, OH | ESPN+ |
| UIC Flames vs Valparaiso Crusaders | Saturday, November 13, 2021 | 1:00 PM EST | Athletics-Recreation Center in Valparaiso, IN | ESPN+ |
| Hawaii Warriors vs UIC Flames | Thursday, November 25, 2021 | 4:00 PM EST | Orleans Arena in Las Vegas, NV | ESPN+ |
| Oakland Golden Grizzlies vs UIC Flames | Thursday, December 2, 2021 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Detroit Titans vs UIC Flames | Sunday, December 5, 2021 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| UIC Flames vs Central Michigan Chippewas | Saturday, December 11, 2021 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| DePaul Blue Demons vs UIC Flames | Wednesday, December 15, 2021 | 8:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Northern Illinois Huskies vs UIC Flames | Sunday, December 19, 2021 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| UIC Flames vs Wright State Raiders | Thursday, January 6, 2022 | 7:00 PM EST | Nutter Center in Dayton, OH | ESPN+ |
| UIC Flames vs Northern Kentucky Norse | Saturday, January 8, 2022 | 7:00 PM EST | BB&T Arena in Highland Heights, KY | ESPN+ |
| UIC Flames vs IUPUI Jaguars | Monday, January 10, 2022 | 7:00 PM EST | Indiana Farmers Coliseum in Indianapolis, IN | ESPN+ |
| UIC Flames vs Milwaukee Panthers | Thursday, January 13, 2022 | 7:00 PM EST | UW-Milwaukee Panther Arena in Milwaukee, WI | ESPN+ |
| UIC Flames vs Green Bay Phoenix | Saturday, January 15, 2022 | 7:00 PM EST | Resch Center in Ashwaubenon, WI | ESPN+ |
| Northern Kentucky Norse vs UIC Flames | Thursday, January 20, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Wright State Raiders vs UIC Flames | Saturday, January 22, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| UIC Flames vs Detroit Titans | Thursday, January 27, 2022 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Robert Morris Colonials vs UIC Flames | Thursday, February 3, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Youngstown State Penguins vs UIC Flames | Saturday, February 5, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| IUPUI Jaguars vs UIC Flames | Monday, February 14, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| UIC Flames vs Robert Morris Colonials | Saturday, February 19, 2022 | 7:00 PM EST | UPMC Events Center in Moon Township, PA | ESPN+ |
| Green Bay Phoenix vs UIC Flames | Thursday, February 24, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
| Milwaukee Panthers vs UIC Flames | Saturday, February 26, 2022 | 7:00 PM EST | Credit Union 1 Arena in Chicago, IL | ESPN+ |
