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| UMass Lowell River Hawks vs Dayton Flyers | Saturday, November 13, 2021 | 7:00 PM EST | UD Arena in Dayton, OH | ESPN+ |
| UMass Lowell River Hawks vs Oklahoma State Cowboys | Tuesday, November 16, 2021 | 5:00 PM EST | Mohegan Sun Arena in Uncasville, CT | ESPN+ |
| Central Connecticut Blue Devils vs UMass Lowell River Hawks | Wednesday, November 17, 2021 | 5:00 PM EST | Mohegan Sun Arena in Uncasville, CT | ESPN+ |
| UMass Lowell River Hawks vs George Washington Colonials | Friday, November 19, 2021 | 7:00 PM EST | Charles E. Smith Center in Washington, DC | ESPN+ |
| UMass Lowell River Hawks vs UMass Minutemen | Wednesday, November 24, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| Brown Bears vs UMass Lowell River Hawks | Wednesday, December 1, 2021 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Sacred Heart Pioneers vs UMass Lowell River Hawks | Sunday, December 19, 2021 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs LIU Brooklyn Blackbirds | Tuesday, December 21, 2021 | 7:00 PM EST | Steinberg Wellness Center in Brooklyn, NY | ESPN+ |
| St. Francis Brooklyn Terriers vs UMass Lowell River Hawks | Thursday, December 23, 2021 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs Binghamton Bearcats | Sunday, January 2, 2022 | 2:00 PM EST | Events Center (Binghamton) in Binghamton, NY | ESPN+ |
| NJIT Highlanders vs UMass Lowell River Hawks | Wednesday, January 5, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs UMBC Retrievers | Saturday, January 8, 2022 | 7:00 PM EST | UMBC Event Center in Baltimore, MD | ESPN+ |
| UMass Lowell River Hawks vs Albany Great Danes | Wednesday, January 12, 2022 | 7:00 PM EST | SEFCU Arena in Albany, NY | ESPN+ |
| Hartford Hawks vs UMass Lowell River Hawks | Saturday, January 15, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Maine Black Bears vs UMass Lowell River Hawks | Wednesday, January 19, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs New Hampshire Wildcats | Saturday, January 22, 2022 | 7:00 PM EST | Lundholm Gymnasium in Durham, NH | ESPN+ |
| Albany Great Danes vs UMass Lowell River Hawks | Wednesday, January 26, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Vermont Catamounts vs UMass Lowell River Hawks | Saturday, February 5, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs Stony Brook Seawolves | Wednesday, February 9, 2022 | 7:00 PM EST | Island FCU Arena in Stony Brook, NY | ESPN+ |
| UMBC Retrievers vs UMass Lowell River Hawks | Saturday, February 12, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Binghamton Bearcats vs UMass Lowell River Hawks | Saturday, February 19, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| Stony Brook Seawolves vs UMass Lowell River Hawks | Wednesday, February 23, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
| UMass Lowell River Hawks vs Vermont Catamounts | Saturday, February 26, 2022 | 7:00 PM EST | Patrick Gymnasium in Burlington, VT | ESPN+ |
| New Hampshire Wildcats vs UMass Lowell River Hawks | Tuesday, March 1, 2022 | 7:00 PM EST | Costello Athletic Center in Lowell, MA | ESPN+ |
