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| UMBC Retrievers vs UMass Minutemen | Tuesday, November 9, 2021 | 4:30 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Yale Bulldogs | Friday, November 12, 2021 | 8:00 PM EST | John J. Lee Amphitheater in New Haven, CT | ESPN+ |
| Penn State Nittany Lions vs UMass Minutemen | Monday, November 15, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Weber State Wildcats | Thursday, November 18, 2021 | 5:30 PM EST | McArthur Center in Saint Petersburg, FL | ESPN+ |
| UMass Minutemen vs UNC Greensboro Spartans | Friday, November 19, 2021 | 3:00 PM EST | McArthur Center in Saint Petersburg, FL | ESPN+ |
| UMass Minutemen vs Ball State Cardinals | Sunday, November 21, 2021 | 2:30 PM EST | McArthur Center in Saint Petersburg, FL | ESPN+ |
| UMass Lowell River Hawks vs UMass Minutemen | Wednesday, November 24, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| Rutgers Scarlet Knights vs UMass Minutemen | Saturday, November 27, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Northeastern Huskies | Tuesday, December 7, 2021 | 7:00 PM EST | Matthews Arena in Boston, MA | ESPN+ |
| UMass Minutemen vs North Texas Mean Green | Saturday, December 11, 2021 | 7:00 PM EST | Dickies Arena in Fort Worth, TX | ESPN+ |
| Fairfield Stags vs UMass Minutemen | Sunday, December 19, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| NJIT Highlanders vs UMass Minutemen | Wednesday, December 22, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| Saint Louis Billikens vs UMass Minutemen | Thursday, December 30, 2021 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Fordham Rams | Sunday, January 2, 2022 | 7:00 PM EST | Rose Hill Gymnasium in Bronx, NY | ESPN+ |
| UMass Minutemen vs Richmond Spiders | Thursday, January 6, 2022 | 7:00 PM EST | Robins Center in Richmond, VA | ESPN+ |
| Duquesne Dukes vs UMass Minutemen | Saturday, January 8, 2022 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Davidson Wildcats | Tuesday, January 11, 2022 | 7:00 PM EST | John M. Belk Arena in Davidson, NC | ESPN+ |
| Rhode Island Rams vs UMass Minutemen | Saturday, January 15, 2022 | 4:30 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Saint Louis Billikens | Sunday, January 23, 2022 | 2:30 PM EST | Chaifetz Arena in St. Louis, MO | ESPN+ |
| UMass Minutemen vs La Salle Explorers | Wednesday, January 26, 2022 | 7:00 PM EST | Tom Gola Arena in Philadelphia, PA | ESPN+ |
| George Mason Patriots vs UMass Minutemen | Sunday, January 30, 2022 | 2:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Rhode Island Rams | Saturday, February 5, 2022 | 7:00 PM EST | Ryan Center in Kingston, RI | ESPN+ |
| George Washington Colonials vs UMass Minutemen | Wednesday, February 9, 2022 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| Saint Joseph’s Hawks vs UMass Minutemen | Saturday, February 12, 2022 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| La Salle Explorers vs UMass Minutemen | Saturday, February 19, 2022 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| UMass Minutemen vs Dayton Flyers | Wednesday, February 23, 2022 | 7:00 PM EST | UD Arena in Dayton, OH | ESPN+ |
| VCU Rams vs UMass Minutemen | Saturday, February 26, 2022 | 4:30 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
| Fordham Rams vs UMass Minutemen | Wednesday, March 2, 2022 | 7:00 PM EST | William D. Mullins Memorial Center in Amherst, MA | ESPN+ |
