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| Alabama State Hornets vs Vanderbilt Commodores | Wednesday, November 10, 2021 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| VCU Rams vs Vanderbilt Commodores | Wednesday, November 17, 2021 | 6:30 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Vanderbilt Commodores vs Pittsburgh Panthers | Thursday, November 25, 2021 | 9:00 PM EST | Petersen Events Center in Pittsburgh, PA | ACC Network |
| MVSU Delta Devils vs Vanderbilt Commodores | Tuesday, November 30, 2021 | 8:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Temple Owls vs Vanderbilt Commodores | Tuesday, December 7, 2021 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Loyola Ramblers vs Vanderbilt Commodores | Friday, December 10, 2021 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Austin Peay Governors vs Vanderbilt Commodores | Saturday, December 18, 2021 | 2:30 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Vanderbilt Commodores vs Hawaii Warriors | Thursday, December 23, 2021 | 11:59 PM EST | Stan Sheriff Center in Honolulu, HI | ESPN2 |
| Vanderbilt Commodores vs Arkansas Razorbacks | Wednesday, January 5, 2022 | 8:30 PM EST | Bud Walton Arena in Fayetteville, AR | SEC Network |
| South Carolina Gamecocks vs Vanderbilt Commodores | Saturday, January 8, 2022 | 12:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPNU |
| Kentucky Wildcats vs Vanderbilt Commodores | Wednesday, January 12, 2022 | 7:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | ESPN+ |
| Vanderbilt Commodores vs Georgia Bulldogs | Saturday, January 15, 2022 | 7:00 PM EST | Stegeman Coliseum in Athens, GA | ESPNU |
| Tennessee Volunteers vs Vanderbilt Commodores | Wednesday, January 19, 2022 | 9:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Vanderbilt Commodores vs Florida Gators | Saturday, January 22, 2022 | 1:00 PM EST | Exactech Arena at Stephen C. O’Connell Center in Gainesville, FL | SEC Network |
| Vanderbilt Commodores vs South Carolina Gamecocks | Thursday, January 27, 2022 | 7:00 PM EST | Colonial Life Arena in Columbia, SC | ESPNU |
| LSU Tigers vs Vanderbilt Commodores | Saturday, February 5, 2022 | 6:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Vanderbilt Commodores vs Tennessee Volunteers | Saturday, February 12, 2022 | 6:00 PM EST | Thompson-Boling Arena in Knoxville, TN | SEC Network |
| Texas A&M Aggies vs Vanderbilt Commodores | Saturday, February 19, 2022 | 6:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Alabama Crimson Tide vs Vanderbilt Commodores | Wednesday, February 23, 2022 | 9:00 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
| Vanderbilt Commodores vs Mississippi State Bulldogs | Saturday, February 26, 2022 | 1:00 PM EST | Humphrey Coliseum in Starkville, MS | SEC Network |
| Florida Gators vs Vanderbilt Commodores | Wednesday, March 2, 2022 | 8:30 PM EST | Memorial Gymnasium (Vanderbilt) in Nashville, TN | SEC Network |
