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| Mount St. Mary’s Mountaineers vs Villanova Wildcats | Tuesday, November 9, 2021 | 4:30 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Villanova Wildcats vs UCLA Bruins | Saturday, November 13, 2021 | 11:30 PM EST | Pauley Pavilion presented by Wescom in Los Angeles, CA | ESPN2 |
| Howard Bison vs Villanova Wildcats | Tuesday, November 16, 2021 | 6:30 PM EST | Finneran Pavilion in Villanova, PA | FS2 |
| Villanova Wildcats vs La Salle Explorers | Sunday, November 28, 2021 | 6:00 PM EST | Tom Gola Arena in Philadelphia, PA | ESPN2 |
| Villanova Wildcats vs Penn Quakers | Thursday, December 2, 2021 | 7:00 PM EST | The Palestra in Philadelphia, PA | ESPN+ |
| Villanova Wildcats vs Syracuse Orange | Wednesday, December 8, 2021 | 9:30 PM EST | Madison Square Garden in New York, NY | ESPN |
| Villanova Wildcats vs Baylor Bears | Sunday, December 12, 2021 | 3:00 PM EST | Ferrell Center in Waco, TX | ABC |
| Villanova Wildcats vs Creighton Bluejays | Friday, December 17, 2021 | 7:00 PM EST | CHI Health Center Omaha in Omaha, NE | FS1 |
| Xavier Musketeers vs Villanova Wildcats | Wednesday, December 22, 2021 | 7:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Temple Owls vs Villanova Wildcats | Thursday, December 30, 2021 | 9:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Creighton Bluejays vs Villanova Wildcats | Thursday, January 6, 2022 | 8:30 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Villanova Wildcats vs DePaul Blue Demons | Saturday, January 8, 2022 | 7:00 PM EST | Wintrust Arena in Chicago, IL | FS1 |
| Villanova Wildcats vs Xavier Musketeers | Wednesday, January 12, 2022 | 6:30 PM EST | Cintas Center in Cincinnati, OH | FS1 |
| Butler Bulldogs vs Villanova Wildcats | Sunday, January 16, 2022 | 12:00 PM EST | Wells Fargo Center in Philadelphia, PA | FS1 |
| Marquette Golden Eagles vs Villanova Wildcats | Thursday, January 20, 2022 | 8:00 PM EST | Finneran Pavilion in Villanova, PA | CBSSN |
| Villanova Wildcats vs Georgetown Hoyas | Saturday, January 22, 2022 | 12:00 PM EST | Capital One Arena in Washington, DC | FOX |
| DePaul Blue Demons vs Villanova Wildcats | Tuesday, January 25, 2022 | 5:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
| Connecticut Huskies vs Villanova Wildcats | Saturday, February 5, 2022 | 12:00 PM EST | Wells Fargo Center in Philadelphia, PA | FOX |
| Seton Hall Pirates vs Villanova Wildcats | Saturday, February 12, 2022 | 1:00 PM EST | Wells Fargo Center in Philadelphia, PA | FOX |
| Villanova Wildcats vs Providence Friars | Wednesday, February 16, 2022 | 8:00 PM EST | Dunkin Donuts Center in Providence, RI | CBSSN |
| Georgetown Hoyas vs Villanova Wildcats | Saturday, February 19, 2022 | 5:00 PM EST | Finneran Pavilion in Villanova, PA | FOX |
| Villanova Wildcats vs Connecticut Huskies | Wednesday, February 23, 2022 | 8:00 PM EST | XL Center in Hartford, CT | FS1 |
| Providence Friars vs Villanova Wildcats | Wednesday, March 2, 2022 | 7:00 PM EST | Finneran Pavilion in Villanova, PA | FS1 |
