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| Western Michigan Broncos vs Michigan State Spartans | Friday, November 12, 2021 | 7:00 PM EST | Breslin Center in East Lansing, MI | BTN |
| Western Michigan Broncos vs Iowa Hawkeyes | Tuesday, November 23, 2021 | 8:30 PM EST | Carver-Hawkeye Arena in Iowa City, IA | BTN |
| Western Michigan Broncos vs Florida Gulf Coast Eagles | Friday, November 26, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Western Michigan Broncos vs SE Louisiana Lions | Sunday, November 28, 2021 | 7:00 PM EST | Alico Arena in Fort Myers, FL | ESPN+ |
| Valparaiso Crusaders vs Western Michigan Broncos | Sunday, December 5, 2021 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Detroit Titans | Saturday, December 11, 2021 | 7:00 PM EST | Calihan Hall in Detroit, MI | ESPN+ |
| Western Michigan Broncos vs Notre Dame Fighting Irish | Tuesday, December 21, 2021 | 8:00 PM EST | Purcell Pavilion in South Bend, IN | ACC Network |
| Western Michigan Broncos vs Toledo Rockets | Tuesday, December 28, 2021 | 7:00 PM EST | Savage Arena in Toledo, OH | ESPN+ |
| Eastern Michigan Eagles vs Western Michigan Broncos | Tuesday, January 4, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Central Michigan Chippewas | Saturday, January 8, 2022 | 7:00 PM EST | McGuirk Arena in Mount Pleasant, MI | ESPN+ |
| Buffalo Bulls vs Western Michigan Broncos | Tuesday, January 11, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Miami RedHawks vs Western Michigan Broncos | Saturday, January 15, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Akron Zips | Tuesday, January 18, 2022 | 7:00 PM EST | James A. Rhodes Arena in Akron, OH | ESPN+ |
| Bowling Green Falcons vs Western Michigan Broncos | Saturday, January 22, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Kent State Golden Flashes | Tuesday, January 25, 2022 | 7:00 PM EST | M.A.C. Center in Kent, OH | ESPN+ |
| Northern Illinois Huskies vs Western Michigan Broncos | Tuesday, February 1, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Ohio Bobcats | Saturday, February 5, 2022 | 7:00 PM EST | Convocation Center (OH) in Athens, OH | ESPN+ |
| Central Michigan Chippewas vs Western Michigan Broncos | Saturday, February 12, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Akron Zips vs Western Michigan Broncos | Tuesday, February 15, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Buffalo Bulls | Saturday, February 19, 2022 | 7:00 PM EST | Alumni Arena in Buffalo, NY | ESPN+ |
| Toledo Rockets vs Western Michigan Broncos | Tuesday, February 22, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Western Michigan Broncos vs Bowling Green Falcons | Saturday, February 26, 2022 | 7:00 PM EST | Stroh Center in Bowling Green, OH | ESPN+ |
| Eastern Michigan Eagles vs Western Michigan Broncos | Wednesday, March 2, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
| Ball State Cardinals vs Western Michigan Broncos | Friday, March 4, 2022 | 7:00 PM EST | University Arena (MI) in Kalamazoo, MI | ESPN+ |
