|
| Wofford Terriers vs Clemson Tigers | Friday, November 12, 2021 | 7:00 PM EST | Littlejohn Coliseum in Clemson, SC | ESPN+ |
| Hampton Pirates vs Wofford Terriers | Saturday, November 20, 2021 | 7:30 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Georgia Southern Eagles vs Wofford Terriers | Sunday, November 21, 2021 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs South Carolina Gamecocks | Tuesday, November 23, 2021 | 7:00 PM EST | Colonial Life Arena in Columbia, SC | ESPN+ |
| Wofford Terriers vs Georgia Bulldogs | Sunday, November 28, 2021 | 7:00 PM EST | Stegeman Coliseum in Athens, GA | ESPN+ |
| Richmond Spiders vs Wofford Terriers | Thursday, December 2, 2021 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Kennesaw State Owls vs Wofford Terriers | Sunday, December 5, 2021 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs Gardner-Webb Bulldogs | Wednesday, December 8, 2021 | 7:00 PM EST | Paul Porter Arena in Boiling Springs, NC | ESPN+ |
| Wofford Terriers vs Coastal Carolina Chanticleers | Sunday, December 12, 2021 | 2:00 PM EST | The HTC Center in Conway, SC | ESPN+ |
| Wofford Terriers vs Presbyterian Blue Hose | Saturday, December 18, 2021 | 7:00 PM EST | Ross E. Templeton P.E. Center in Clinton, SC | ESPN+ |
| Wofford Terriers vs Duquesne Dukes | Thursday, December 23, 2021 | 7:00 PM EST | UPMC Cooper Fieldhouse in Pittsburgh, PA | ESPN+ |
| VMI Keydets vs Wofford Terriers | Wednesday, December 29, 2021 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Chattanooga Mocs vs Wofford Terriers | Wednesday, January 5, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs East Tennessee State Buccaneers | Saturday, January 8, 2022 | 7:00 PM EST | Freedom Hall Civic Center in Johnson City, TN | ESPN+ |
| Samford Bulldogs vs Wofford Terriers | Wednesday, January 12, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs Western Carolina Catamounts | Saturday, January 15, 2022 | 7:00 PM EST | Ramsey Regional Activity Center in Cullowhee, NC | ESPN+ |
| Citadel Bulldogs vs Wofford Terriers | Wednesday, January 19, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Furman Paladins vs Wofford Terriers | Saturday, January 22, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs Chattanooga Mocs | Wednesday, January 26, 2022 | 7:00 PM EST | McKenzie Arena in Chattanooga, TN | ESPN+ |
| Wofford Terriers vs Mercer Bears | Tuesday, February 1, 2022 | 7:00 PM EST | Hawkins Arena in Macon, GA | ESPNU |
| East Tennessee State Buccaneers vs Wofford Terriers | Saturday, February 5, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs Samford Bulldogs | Wednesday, February 9, 2022 | 7:00 PM EST | Pete Hanna Center in Birmingham, AL | ESPN+ |
| Western Carolina Catamounts vs Wofford Terriers | Saturday, February 12, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
| Wofford Terriers vs Furman Paladins | Saturday, February 19, 2022 | 7:00 PM EST | Timmons Arena in Greenville, SC | ESPN+ |
| Wofford Terriers vs VMI Keydets | Wednesday, February 23, 2022 | 7:00 PM EST | Cameron Hall in Lexington, VA | ESPN+ |
| Mercer Bears vs Wofford Terriers | Saturday, February 26, 2022 | 7:00 PM EST | Jerry Richardson Indoor Stadium in Spartanburg, SC | ESPN+ |
