| Pittsburgh Steelers vs Buffalo Bills |
Sunday, September 12, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
CBS |
| Buffalo Bills vs Miami Dolphins |
Sunday, September 19, 2021 |
1:00 PM EST |
Hard Rock Stadium in Miami Gardens, FL |
FOX |
| Washington Football Team vs Buffalo Bills |
Sunday, September 26, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
FOX |
| Houston Texans vs Buffalo Bills |
Sunday, October 3, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
CBS |
| Buffalo Bills vs Kansas City Chiefs |
Sunday, October 10, 2021 |
8:20 PM EST |
Arrowhead Stadium in Kansas City, MO |
NBC |
| Buffalo Bills vs Tennessee Titans |
Monday, October 18, 2021 |
8:15 PM EST |
Nissan Stadium in Nashville, TN |
ESPN |
| Miami Dolphins vs Buffalo Bills |
Sunday, October 31, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
CBS |
| Buffalo Bills vs Jacksonville Jaguars |
Sunday, November 7, 2021 |
1:00 PM EST |
TIAA Bank Field in Jacksonville, FL |
CBS |
| Buffalo Bills vs New York Jets |
Sunday, November 14, 2021 |
1:00 PM EST |
MetLife Stadium in East Rutherford, NJ |
CBS |
| Indianapolis Colts vs Buffalo Bills |
Sunday, November 21, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
CBS |
| Buffalo Bills vs New Orleans Saints |
Thursday, November 25, 2021 |
8:20 PM EST |
Caesars Superdome in New Orleans, LA |
NBC |
| New England Patriots vs Buffalo Bills |
Monday, December 6, 2021 |
8:15 PM EST |
Highmark Stadium in Orchard Park, NY |
ESPN |
| Buffalo Bills vs Tampa Bay Buccaneers |
Sunday, December 12, 2021 |
4:25 PM EST |
Raymond James Stadium in Tampa, FL |
CBS |
| Carolina Panthers vs Buffalo Bills |
Sunday, December 19, 2021 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
FOX |
| Buffalo Bills vs New England Patriots |
Sunday, December 26, 2021 |
1:00 PM EST |
Gillette Stadium in Foxborough, MA |
CBS |
| Atlanta Falcons vs Buffalo Bills |
Sunday, January 2, 2022 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
FOX |
| New York Jets vs Buffalo Bills |
Sunday, January 9, 2022 |
1:00 PM EST |
Highmark Stadium in Orchard Park, NY |
CBS |
