|
| Chicago White Sox vs Los Angeles Angels | Thursday, April 1, 2021 | 10:05 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| Chicago White Sox vs Los Angeles Angels | Friday, April 2, 2021 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| Chicago White Sox vs Los Angeles Angels | Saturday, April 3, 2021 | 9:07 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| Chicago White Sox vs Los Angeles Angels | Sunday, April 4, 2021 | 8:37 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| Chicago White Sox vs Seattle Mariners | Monday, April 5, 2021 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Chicago White Sox vs Seattle Mariners | Tuesday, April 6, 2021 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Chicago White Sox vs Seattle Mariners | Wednesday, April 7, 2021 | 4:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Kansas City Royals vs Chicago White Sox | Thursday, April 8, 2021 | 4:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Saturday, April 10, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Sunday, April 11, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Monday, April 12, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Tuesday, April 13, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Wednesday, April 14, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Thursday, April 15, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Boston Red Sox | Friday, April 16, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Chicago White Sox vs Boston Red Sox | Saturday, April 17, 2021 | 4:05 PM EST | Fenway Park in Boston, MA | NESN |
| Chicago White Sox vs Boston Red Sox | Sunday, April 18, 2021 | 1:10 PM EST | Fenway Park in Boston, MA | NESN |
| Chicago White Sox vs Boston Red Sox | Monday, April 19, 2021 | 11:10 AM EST | Fenway Park in Boston, MA | NESN |
| Chicago White Sox vs Cleveland Indians | Tuesday, April 20, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Wednesday, April 21, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Texas Rangers vs Chicago White Sox | Friday, April 23, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Texas Rangers vs Chicago White Sox | Saturday, April 24, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Texas Rangers vs Chicago White Sox | Sunday, April 25, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Tuesday, April 27, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Wednesday, April 28, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Thursday, April 29, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Friday, April 30, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Saturday, May 1, 2021 | 4:05 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Sunday, May 2, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Cincinnati Reds | Tuesday, May 4, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Chicago White Sox vs Cincinnati Reds | Wednesday, May 5, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Chicago White Sox vs Kansas City Royals | Friday, May 7, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Saturday, May 8, 2021 | 7:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Sunday, May 9, 2021 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Minnesota Twins vs Chicago White Sox | Tuesday, May 11, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Wednesday, May 12, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Thursday, May 13, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Friday, May 14, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Saturday, May 15, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Sunday, May 16, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Minnesota Twins | Monday, May 17, 2021 | 7:40 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Tuesday, May 18, 2021 | 7:40 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Wednesday, May 19, 2021 | 1:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs New York Yankees | Friday, May 21, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Chicago White Sox vs New York Yankees | Saturday, May 22, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Chicago White Sox vs New York Yankees | Sunday, May 23, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| St. Louis Cardinals vs Chicago White Sox | Monday, May 24, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| St. Louis Cardinals vs Chicago White Sox | Tuesday, May 25, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| St. Louis Cardinals vs Chicago White Sox | Wednesday, May 26, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Baltimore Orioles vs Chicago White Sox | Thursday, May 27, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Baltimore Orioles vs Chicago White Sox | Friday, May 28, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Baltimore Orioles vs Chicago White Sox | Saturday, May 29, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Baltimore Orioles vs Chicago White Sox | Sunday, May 30, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Cleveland Indians | Monday, May 31, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Tuesday, June 1, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Wednesday, June 2, 2021 | 1:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Detroit Tigers vs Chicago White Sox | Thursday, June 3, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Friday, June 4, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Saturday, June 5, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Sunday, June 6, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Toronto Blue Jays vs Chicago White Sox | Tuesday, June 8, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Toronto Blue Jays vs Chicago White Sox | Wednesday, June 9, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Toronto Blue Jays vs Chicago White Sox | Thursday, June 10, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Detroit Tigers | Friday, June 11, 2021 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Saturday, June 12, 2021 | 4:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Sunday, June 13, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Tampa Bay Rays vs Chicago White Sox | Monday, June 14, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Tampa Bay Rays vs Chicago White Sox | Tuesday, June 15, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Tampa Bay Rays vs Chicago White Sox | Wednesday, June 16, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Houston Astros | Thursday, June 17, 2021 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Chicago White Sox vs Houston Astros | Friday, June 18, 2021 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Chicago White Sox vs Houston Astros | Saturday, June 19, 2021 | 7:15 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Chicago White Sox vs Houston Astros | Sunday, June 20, 2021 | 2:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Chicago White Sox vs Pittsburgh Pirates | Tuesday, June 22, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago White Sox vs Pittsburgh Pirates | Wednesday, June 23, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Seattle Mariners vs Chicago White Sox | Friday, June 25, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Seattle Mariners vs Chicago White Sox | Saturday, June 26, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Seattle Mariners vs Chicago White Sox | Sunday, June 27, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Monday, June 28, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Tuesday, June 29, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Wednesday, June 30, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Thursday, July 1, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Detroit Tigers | Friday, July 2, 2021 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Saturday, July 3, 2021 | 4:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Sunday, July 4, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Minnesota Twins | Monday, July 5, 2021 | 7:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Tuesday, July 6, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Wednesday, July 7, 2021 | 1:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Baltimore Orioles | Friday, July 9, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| Chicago White Sox vs Baltimore Orioles | Saturday, July 10, 2021 | 4:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| Chicago White Sox vs Baltimore Orioles | Sunday, July 11, 2021 | 1:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| Houston Astros vs Chicago White Sox | Friday, July 16, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Houston Astros vs Chicago White Sox | Saturday, July 17, 2021 | 7:15 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Houston Astros vs Chicago White Sox | Sunday, July 18, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Monday, July 19, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Tuesday, July 20, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Minnesota Twins vs Chicago White Sox | Wednesday, July 21, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Milwaukee Brewers | Friday, July 23, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Chicago White Sox vs Milwaukee Brewers | Saturday, July 24, 2021 | 7:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Chicago White Sox vs Milwaukee Brewers | Sunday, July 25, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Chicago White Sox vs Kansas City Royals | Monday, July 26, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Tuesday, July 27, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Wednesday, July 28, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Thursday, July 29, 2021 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Indians vs Chicago White Sox | Friday, July 30, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Saturday, July 31, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Indians vs Chicago White Sox | Sunday, August 1, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Tuesday, August 3, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Wednesday, August 4, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Kansas City Royals vs Chicago White Sox | Thursday, August 5, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Chicago Cubs | Friday, August 6, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Chicago White Sox vs Chicago Cubs | Saturday, August 7, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Chicago White Sox vs Chicago Cubs | Sunday, August 8, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Chicago White Sox vs Minnesota Twins | Monday, August 9, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Tuesday, August 10, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Chicago White Sox vs Minnesota Twins | Wednesday, August 11, 2021 | 1:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| New York Yankees vs Chicago White Sox | Thursday, August 12, 2021 | 7:15 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| New York Yankees vs Chicago White Sox | Saturday, August 14, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| New York Yankees vs Chicago White Sox | Sunday, August 15, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Oakland Athletics vs Chicago White Sox | Monday, August 16, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Oakland Athletics vs Chicago White Sox | Tuesday, August 17, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Oakland Athletics vs Chicago White Sox | Wednesday, August 18, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Oakland Athletics vs Chicago White Sox | Thursday, August 19, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Tampa Bay Rays | Friday, August 20, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Chicago White Sox vs Tampa Bay Rays | Saturday, August 21, 2021 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Chicago White Sox vs Tampa Bay Rays | Sunday, August 22, 2021 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Chicago White Sox vs Toronto Blue Jays | Monday, August 23, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Chicago White Sox vs Toronto Blue Jays | Tuesday, August 24, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Chicago White Sox vs Toronto Blue Jays | Wednesday, August 25, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Chicago White Sox vs Toronto Blue Jays | Thursday, August 26, 2021 | 3:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Chicago Cubs vs Chicago White Sox | Friday, August 27, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago Cubs vs Chicago White Sox | Saturday, August 28, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago Cubs vs Chicago White Sox | Sunday, August 29, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Pittsburgh Pirates vs Chicago White Sox | Tuesday, August 31, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Pittsburgh Pirates vs Chicago White Sox | Wednesday, September 1, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Kansas City Royals | Friday, September 3, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Saturday, September 4, 2021 | 7:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Kansas City Royals | Sunday, September 5, 2021 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Oakland Athletics | Tuesday, September 7, 2021 | 9:40 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| Chicago White Sox vs Oakland Athletics | Wednesday, September 8, 2021 | 9:40 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| Chicago White Sox vs Oakland Athletics | Thursday, September 9, 2021 | 3:37 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| Boston Red Sox vs Chicago White Sox | Friday, September 10, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Boston Red Sox vs Chicago White Sox | Saturday, September 11, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Boston Red Sox vs Chicago White Sox | Sunday, September 12, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Los Angeles Angels vs Chicago White Sox | Tuesday, September 14, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Los Angeles Angels vs Chicago White Sox | Wednesday, September 15, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Los Angeles Angels vs Chicago White Sox | Thursday, September 16, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Chicago White Sox vs Texas Rangers | Friday, September 17, 2021 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Chicago White Sox vs Texas Rangers | Saturday, September 18, 2021 | 7:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Chicago White Sox vs Texas Rangers | Sunday, September 19, 2021 | 2:35 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Chicago White Sox vs Detroit Tigers | Monday, September 20, 2021 | 6:40 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Tuesday, September 21, 2021 | 6:40 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Detroit Tigers | Wednesday, September 22, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Chicago White Sox vs Cleveland Indians | Thursday, September 23, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Friday, September 24, 2021 | 7:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Saturday, September 25, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Chicago White Sox vs Cleveland Indians | Sunday, September 26, 2021 | 1:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Cincinnati Reds vs Chicago White Sox | Tuesday, September 28, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cincinnati Reds vs Chicago White Sox | Wednesday, September 29, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Friday, October 1, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Saturday, October 2, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Detroit Tigers vs Chicago White Sox | Sunday, October 3, 2021 | 3:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
