| Cleveland Guardians vs Kansas City Royals | Friday, April 8, 2022 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Saturday, April 9, 2022 | 4:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Sunday, April 10, 2022 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Monday, April 11, 2022 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Cincinnati Reds | Tuesday, April 12, 2022 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Cleveland Guardians vs Cincinnati Reds | Wednesday, April 13, 2022 | 12:35 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| San Francisco Giants vs Cleveland Guardians | Friday, April 15, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| San Francisco Giants vs Cleveland Guardians | Saturday, April 16, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| San Francisco Giants vs Cleveland Guardians | Sunday, April 17, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Monday, April 18, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Tuesday, April 19, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Wednesday, April 20, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Thursday, April 21, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs New York Yankees | Friday, April 22, 2022 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Cleveland Guardians vs New York Yankees | Saturday, April 23, 2022 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Cleveland Guardians vs New York Yankees | Sunday, April 24, 2022 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Cleveland Guardians vs Los Angeles Angels | Monday, April 25, 2022 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports SoCal |
| Cleveland Guardians vs Los Angeles Angels | Tuesday, April 26, 2022 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports SoCal |
| Cleveland Guardians vs Los Angeles Angels | Wednesday, April 27, 2022 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports SoCal |
| Cleveland Guardians vs Los Angeles Angels | Thursday, April 28, 2022 | 4:07 PM EST | Angel Stadium in Anaheim, CA | Bally Sports SoCal |
| Cleveland Guardians vs Oakland Athletics | Friday, April 29, 2022 | 9:40 PM EST | Oakland Coliseum in Oakland, CA | NBC Sports California |
| Cleveland Guardians vs Oakland Athletics | Saturday, April 30, 2022 | 4:07 PM EST | Oakland Coliseum in Oakland, CA | NBC Sports California |
| Cleveland Guardians vs Oakland Athletics | Sunday, May 1, 2022 | 4:07 PM EST | Oakland Coliseum in Oakland, CA | NBC Sports California |
| San Diego Padres vs Cleveland Guardians | Tuesday, May 3, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| San Diego Padres vs Cleveland Guardians | Wednesday, May 4, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Toronto Blue Jays vs Cleveland Guardians | Thursday, May 5, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Toronto Blue Jays vs Cleveland Guardians | Friday, May 6, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Toronto Blue Jays vs Cleveland Guardians | Saturday, May 7, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Toronto Blue Jays vs Cleveland Guardians | Sunday, May 8, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Chicago White Sox | Monday, May 9, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Tuesday, May 10, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Wednesday, May 11, 2022 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Minnesota Twins | Friday, May 13, 2022 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Saturday, May 14, 2022 | 7:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Sunday, May 15, 2022 | 2:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cincinnati Reds vs Cleveland Guardians | Tuesday, May 17, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cincinnati Reds vs Cleveland Guardians | Wednesday, May 18, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Friday, May 20, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Saturday, May 21, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Sunday, May 22, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Houston Astros | Monday, May 23, 2022 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Cleveland Guardians vs Houston Astros | Tuesday, May 24, 2022 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Cleveland Guardians vs Houston Astros | Wednesday, May 25, 2022 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Cleveland Guardians vs Detroit Tigers | Thursday, May 26, 2022 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Friday, May 27, 2022 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Saturday, May 28, 2022 | 4:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Sunday, May 29, 2022 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Kansas City Royals vs Cleveland Guardians | Monday, May 30, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Kansas City Royals vs Cleveland Guardians | Tuesday, May 31, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Kansas City Royals vs Cleveland Guardians | Wednesday, June 1, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Baltimore Orioles | Friday, June 3, 2022 | 7:05 PM EST | Oriole Park at Camden Yards in Baltimore, MD | MASN |
| Cleveland Guardians vs Baltimore Orioles | Saturday, June 4, 2022 | 4:05 PM EST | Oriole Park at Camden Yards in Baltimore, MD | MASN |
| Cleveland Guardians vs Baltimore Orioles | Sunday, June 5, 2022 | 1:05 PM EST | Oriole Park at Camden Yards in Baltimore, MD | MASN |
| Texas Rangers vs Cleveland Guardians | Monday, June 6, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Texas Rangers vs Cleveland Guardians | Tuesday, June 7, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Texas Rangers vs Cleveland Guardians | Wednesday, June 8, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Oakland Athletics vs Cleveland Guardians | Thursday, June 9, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Oakland Athletics vs Cleveland Guardians | Friday, June 10, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Oakland Athletics vs Cleveland Guardians | Saturday, June 11, 2022 | 4:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Oakland Athletics vs Cleveland Guardians | Sunday, June 12, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Colorado Rockies | Tuesday, June 14, 2022 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Cleveland Guardians vs Colorado Rockies | Wednesday, June 15, 2022 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Cleveland Guardians vs Colorado Rockies | Thursday, June 16, 2022 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Cleveland Guardians vs Los Angeles Dodgers | Friday, June 17, 2022 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum SportsNet LA |
| Cleveland Guardians vs Los Angeles Dodgers | Saturday, June 18, 2022 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum SportsNet LA |
| Cleveland Guardians vs Los Angeles Dodgers | Sunday, June 19, 2022 | 4:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum SportsNet LA |
| Cleveland Guardians vs Minnesota Twins | Tuesday, June 21, 2022 | 7:40 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Wednesday, June 22, 2022 | 7:40 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Thursday, June 23, 2022 | 1:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Boston Red Sox vs Cleveland Guardians | Friday, June 24, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Boston Red Sox vs Cleveland Guardians | Saturday, June 25, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Boston Red Sox vs Cleveland Guardians | Sunday, June 26, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Monday, June 27, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Tuesday, June 28, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Wednesday, June 29, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Thursday, June 30, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| New York Yankees vs Cleveland Guardians | Friday, July 1, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| New York Yankees vs Cleveland Guardians | Saturday, July 2, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| New York Yankees vs Cleveland Guardians | Sunday, July 3, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Detroit Tigers | Monday, July 4, 2022 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Tuesday, July 5, 2022 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Wednesday, July 6, 2022 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Kansas City Royals | Friday, July 8, 2022 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Saturday, July 9, 2022 | 4:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Sunday, July 10, 2022 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Chicago White Sox vs Cleveland Guardians | Monday, July 11, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Tuesday, July 12, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Wednesday, July 13, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Friday, July 15, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Saturday, July 16, 2022 | 4:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Sunday, July 17, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Chicago White Sox | Friday, July 22, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Saturday, July 23, 2022 | 7:15 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Sunday, July 24, 2022 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Boston Red Sox | Monday, July 25, 2022 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Cleveland Guardians vs Boston Red Sox | Tuesday, July 26, 2022 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Cleveland Guardians vs Boston Red Sox | Wednesday, July 27, 2022 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Cleveland Guardians vs Boston Red Sox | Thursday, July 28, 2022 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Cleveland Guardians vs Tampa Bay Rays | Friday, July 29, 2022 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Cleveland Guardians vs Tampa Bay Rays | Saturday, July 30, 2022 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Cleveland Guardians vs Tampa Bay Rays | Sunday, July 31, 2022 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| Arizona Diamondbacks vs Cleveland Guardians | Monday, August 1, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Arizona Diamondbacks vs Cleveland Guardians | Tuesday, August 2, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Arizona Diamondbacks vs Cleveland Guardians | Wednesday, August 3, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Houston Astros vs Cleveland Guardians | Thursday, August 4, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Houston Astros vs Cleveland Guardians | Friday, August 5, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Houston Astros vs Cleveland Guardians | Saturday, August 6, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Houston Astros vs Cleveland Guardians | Sunday, August 7, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Detroit Tigers | Tuesday, August 9, 2022 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Wednesday, August 10, 2022 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Detroit Tigers | Thursday, August 11, 2022 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Cleveland Guardians vs Toronto Blue Jays | Friday, August 12, 2022 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Cleveland Guardians vs Toronto Blue Jays | Saturday, August 13, 2022 | 3:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Cleveland Guardians vs Toronto Blue Jays | Sunday, August 14, 2022 | 1:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Detroit Tigers vs Cleveland Guardians | Monday, August 15, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Tuesday, August 16, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Detroit Tigers vs Cleveland Guardians | Wednesday, August 17, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Friday, August 19, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Saturday, August 20, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Chicago White Sox vs Cleveland Guardians | Sunday, August 21, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs San Diego Padres | Tuesday, August 23, 2022 | 9:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Cleveland Guardians vs San Diego Padres | Wednesday, August 24, 2022 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Cleveland Guardians vs Seattle Mariners | Thursday, August 25, 2022 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Cleveland Guardians vs Seattle Mariners | Friday, August 26, 2022 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Cleveland Guardians vs Seattle Mariners | Saturday, August 27, 2022 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Cleveland Guardians vs Seattle Mariners | Sunday, August 28, 2022 | 4:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| Baltimore Orioles vs Cleveland Guardians | Tuesday, August 30, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Baltimore Orioles vs Cleveland Guardians | Wednesday, August 31, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Baltimore Orioles vs Cleveland Guardians | Thursday, September 1, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Seattle Mariners vs Cleveland Guardians | Friday, September 2, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Seattle Mariners vs Cleveland Guardians | Saturday, September 3, 2022 | 7:15 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Seattle Mariners vs Cleveland Guardians | Sunday, September 4, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Kansas City Royals | Monday, September 5, 2022 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Tuesday, September 6, 2022 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Kansas City Royals | Wednesday, September 7, 2022 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Cleveland Guardians vs Minnesota Twins | Friday, September 9, 2022 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Saturday, September 10, 2022 | 7:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Cleveland Guardians vs Minnesota Twins | Sunday, September 11, 2022 | 2:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Los Angeles Angels vs Cleveland Guardians | Monday, September 12, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Los Angeles Angels vs Cleveland Guardians | Tuesday, September 13, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Los Angeles Angels vs Cleveland Guardians | Wednesday, September 14, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Friday, September 16, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Saturday, September 17, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Minnesota Twins vs Cleveland Guardians | Sunday, September 18, 2022 | 1:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Cleveland Guardians vs Chicago White Sox | Tuesday, September 20, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Wednesday, September 21, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Chicago White Sox | Thursday, September 22, 2022 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Cleveland Guardians vs Texas Rangers | Friday, September 23, 2022 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Cleveland Guardians vs Texas Rangers | Saturday, September 24, 2022 | 7:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Cleveland Guardians vs Texas Rangers | Sunday, September 25, 2022 | 2:35 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Tampa Bay Rays vs Cleveland Guardians | Tuesday, September 27, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Tampa Bay Rays vs Cleveland Guardians | Wednesday, September 28, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Tampa Bay Rays vs Cleveland Guardians | Thursday, September 29, 2022 | 6:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
| Kansas City Royals vs Cleveland Guardians | Friday, September 30, 2022 | 7:10 PM EST | Progressive Field in Cleveland, OH | Bally Sports Great Lakes |
