| San Francisco 49ers vs Detroit Lions |
Sunday, September 12, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
| Detroit Lions vs Green Bay Packers |
Monday, September 20, 2021 |
8:15 PM EST |
Lambeau Field in Green Bay, WI |
ESPN |
| Baltimore Ravens vs Detroit Lions |
Sunday, September 26, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
CBS |
| Detroit Lions vs Chicago Bears |
Sunday, October 3, 2021 |
1:00 PM EST |
Soldier Field in Chicago, IL |
FOX |
| Detroit Lions vs Minnesota Vikings |
Sunday, October 10, 2021 |
1:00 PM EST |
U.S. Bank Stadium in Minneapolis, MN |
FOX |
| Cincinnati Bengals vs Detroit Lions |
Sunday, October 17, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
| Detroit Lions vs Los Angeles Rams |
Sunday, October 24, 2021 |
4:05 PM EST |
SoFi Stadium in Inglewood, CA |
FOX |
| Philadelphia Eagles vs Detroit Lions |
Sunday, October 31, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
| Detroit Lions vs Pittsburgh Steelers |
Sunday, November 14, 2021 |
1:00 PM EST |
Heinz Field in Pittsburgh, PA |
FOX |
| Detroit Lions vs Cleveland Browns |
Sunday, November 21, 2021 |
1:00 PM EST |
FirstEnergy Stadium in Cleveland, OH |
FOX |
| Chicago Bears vs Detroit Lions |
Thursday, November 25, 2021 |
12:30 PM EST |
Ford Field in Detroit, MI |
FOX |
| Minnesota Vikings vs Detroit Lions |
Sunday, December 5, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
CBS |
| Detroit Lions vs Denver Broncos |
Sunday, December 12, 2021 |
4:05 PM EST |
Empower Field at Mile High in Denver, CO |
FOX |
| Arizona Cardinals vs Detroit Lions |
Sunday, December 19, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
| Detroit Lions vs Atlanta Falcons |
Sunday, December 26, 2021 |
1:00 PM EST |
Mercedes-Benz Stadium in Atlanta, GA |
FOX |
| Detroit Lions vs Seattle Seahawks |
Sunday, January 2, 2022 |
4:25 PM EST |
Lumen Field in Seattle, WA |
FOX |
| Green Bay Packers vs Detroit Lions |
Sunday, January 9, 2022 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
