|
| Toronto Blue Jays vs New York Yankees | Thursday, April 1, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Saturday, April 3, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Sunday, April 4, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Monday, April 5, 2021 | 6:35 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Tuesday, April 6, 2021 | 6:35 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Wednesday, April 7, 2021 | 6:35 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Tampa Bay Rays | Friday, April 9, 2021 | 3:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Saturday, April 10, 2021 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Sunday, April 11, 2021 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Toronto Blue Jays | Monday, April 12, 2021 | 6:37 PM EST | TD Ballpark in Dunedin, FL | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Tuesday, April 13, 2021 | 6:37 PM EST | TD Ballpark in Dunedin, FL | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Wednesday, April 14, 2021 | 3:07 PM EST | TD Ballpark in Dunedin, FL | Sportsnet |
| Tampa Bay Rays vs New York Yankees | Friday, April 16, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Saturday, April 17, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Sunday, April 18, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Atlanta Braves vs New York Yankees | Tuesday, April 20, 2021 | 6:35 PM EST | Yankee Stadium in Bronx, NY | YES |
| Atlanta Braves vs New York Yankees | Wednesday, April 21, 2021 | 6:35 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Cleveland Indians | Thursday, April 22, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| New York Yankees vs Cleveland Indians | Friday, April 23, 2021 | 7:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| New York Yankees vs Cleveland Indians | Saturday, April 24, 2021 | 6:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| New York Yankees vs Cleveland Indians | Sunday, April 25, 2021 | 1:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| New York Yankees vs Baltimore Orioles | Monday, April 26, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Tuesday, April 27, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Wednesday, April 28, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Thursday, April 29, 2021 | 1:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| Detroit Tigers vs New York Yankees | Friday, April 30, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Detroit Tigers vs New York Yankees | Saturday, May 1, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Detroit Tigers vs New York Yankees | Sunday, May 2, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Houston Astros vs New York Yankees | Tuesday, May 4, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Houston Astros vs New York Yankees | Wednesday, May 5, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Houston Astros vs New York Yankees | Thursday, May 6, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Washington Nationals vs New York Yankees | Friday, May 7, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Washington Nationals vs New York Yankees | Saturday, May 8, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Washington Nationals vs New York Yankees | Sunday, May 9, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Tampa Bay Rays | Tuesday, May 11, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Wednesday, May 12, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Thursday, May 13, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Baltimore Orioles | Friday, May 14, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Saturday, May 15, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Sunday, May 16, 2021 | 1:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Texas Rangers | Monday, May 17, 2021 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| New York Yankees vs Texas Rangers | Tuesday, May 18, 2021 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| New York Yankees vs Texas Rangers | Wednesday, May 19, 2021 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| New York Yankees vs Texas Rangers | Thursday, May 20, 2021 | 2:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| Chicago White Sox vs New York Yankees | Friday, May 21, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Chicago White Sox vs New York Yankees | Saturday, May 22, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Chicago White Sox vs New York Yankees | Sunday, May 23, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Tuesday, May 25, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Wednesday, May 26, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Thursday, May 27, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Detroit Tigers | Friday, May 28, 2021 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| New York Yankees vs Detroit Tigers | Saturday, May 29, 2021 | 4:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| New York Yankees vs Detroit Tigers | Sunday, May 30, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Tampa Bay Rays vs New York Yankees | Monday, May 31, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Tuesday, June 1, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Wednesday, June 2, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Thursday, June 3, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Friday, June 4, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Saturday, June 5, 2021 | 7:15 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Sunday, June 6, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Minnesota Twins | Tuesday, June 8, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| New York Yankees vs Minnesota Twins | Wednesday, June 9, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| New York Yankees vs Minnesota Twins | Thursday, June 10, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| New York Yankees vs Philadelphia Phillies | Saturday, June 12, 2021 | 4:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| New York Yankees vs Philadelphia Phillies | Sunday, June 13, 2021 | 1:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| New York Yankees vs Toronto Blue Jays | Tuesday, June 15, 2021 | 7:07 PM EST | Sahlen Field in Buffalo, NY | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Wednesday, June 16, 2021 | 7:07 PM EST | Sahlen Field in Buffalo, NY | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Thursday, June 17, 2021 | 7:07 PM EST | Sahlen Field in Buffalo, NY | Sportsnet |
| Oakland Athletics vs New York Yankees | Friday, June 18, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Oakland Athletics vs New York Yankees | Saturday, June 19, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Oakland Athletics vs New York Yankees | Sunday, June 20, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Kansas City Royals vs New York Yankees | Tuesday, June 22, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Kansas City Royals vs New York Yankees | Wednesday, June 23, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Kansas City Royals vs New York Yankees | Thursday, June 24, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Boston Red Sox | Friday, June 25, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Saturday, June 26, 2021 | 7:15 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Sunday, June 27, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| Los Angeles Angels vs New York Yankees | Monday, June 28, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Los Angeles Angels vs New York Yankees | Tuesday, June 29, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Los Angeles Angels vs New York Yankees | Wednesday, June 30, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Los Angeles Angels vs New York Yankees | Thursday, July 1, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Mets vs New York Yankees | Friday, July 2, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Mets vs New York Yankees | Saturday, July 3, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Mets vs New York Yankees | Sunday, July 4, 2021 | 7:08 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Seattle Mariners | Tuesday, July 6, 2021 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| New York Yankees vs Seattle Mariners | Wednesday, July 7, 2021 | 10:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| New York Yankees vs Seattle Mariners | Thursday, July 8, 2021 | 4:10 PM EST | T-Mobile Park in Seattle, WA | Root Sports Northwest |
| New York Yankees vs Houston Astros | Friday, July 9, 2021 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| New York Yankees vs Houston Astros | Saturday, July 10, 2021 | 7:15 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| New York Yankees vs Houston Astros | Sunday, July 11, 2021 | 2:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| Boston Red Sox vs New York Yankees | Thursday, July 15, 2021 | 7:08 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Friday, July 16, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Saturday, July 17, 2021 | 7:15 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Sunday, July 18, 2021 | 7:08 PM EST | Yankee Stadium in Bronx, NY | YES |
| Philadelphia Phillies vs New York Yankees | Tuesday, July 20, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Philadelphia Phillies vs New York Yankees | Wednesday, July 21, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Boston Red Sox | Thursday, July 22, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Friday, July 23, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Saturday, July 24, 2021 | 4:05 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Sunday, July 25, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Tampa Bay Rays | Tuesday, July 27, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Wednesday, July 28, 2021 | 7:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Tampa Bay Rays | Thursday, July 29, 2021 | 1:10 PM EST | Tropicana Field in St. Petersburg, FL | Bally Sports Sun |
| New York Yankees vs Miami Marlins | Friday, July 30, 2021 | 7:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| New York Yankees vs Miami Marlins | Saturday, July 31, 2021 | 6:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| New York Yankees vs Miami Marlins | Sunday, August 1, 2021 | 1:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Baltimore Orioles vs New York Yankees | Monday, August 2, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Tuesday, August 3, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Wednesday, August 4, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Seattle Mariners vs New York Yankees | Thursday, August 5, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Seattle Mariners vs New York Yankees | Friday, August 6, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Seattle Mariners vs New York Yankees | Saturday, August 7, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Seattle Mariners vs New York Yankees | Sunday, August 8, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Kansas City Royals | Monday, August 9, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| New York Yankees vs Kansas City Royals | Tuesday, August 10, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| New York Yankees vs Kansas City Royals | Wednesday, August 11, 2021 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| New York Yankees vs Chicago White Sox | Thursday, August 12, 2021 | 7:15 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| New York Yankees vs Chicago White Sox | Saturday, August 14, 2021 | 7:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| New York Yankees vs Chicago White Sox | Sunday, August 15, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Boston Red Sox vs New York Yankees | Tuesday, August 17, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Boston Red Sox vs New York Yankees | Wednesday, August 18, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Minnesota Twins vs New York Yankees | Thursday, August 19, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Minnesota Twins vs New York Yankees | Friday, August 20, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Minnesota Twins vs New York Yankees | Saturday, August 21, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Minnesota Twins vs New York Yankees | Sunday, August 22, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Atlanta Braves | Monday, August 23, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| New York Yankees vs Atlanta Braves | Tuesday, August 24, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| New York Yankees vs Oakland Athletics | Thursday, August 26, 2021 | 9:40 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| New York Yankees vs Oakland Athletics | Friday, August 27, 2021 | 9:40 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| New York Yankees vs Oakland Athletics | Saturday, August 28, 2021 | 4:07 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| New York Yankees vs Oakland Athletics | Sunday, August 29, 2021 | 4:07 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| New York Yankees vs Los Angeles Angels | Monday, August 30, 2021 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| New York Yankees vs Los Angeles Angels | Tuesday, August 31, 2021 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| New York Yankees vs Los Angeles Angels | Wednesday, September 1, 2021 | 7:07 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| Baltimore Orioles vs New York Yankees | Friday, September 3, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Saturday, September 4, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Baltimore Orioles vs New York Yankees | Sunday, September 5, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Monday, September 6, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Tuesday, September 7, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Wednesday, September 8, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Toronto Blue Jays vs New York Yankees | Thursday, September 9, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs New York Mets | Friday, September 10, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| New York Yankees vs New York Mets | Saturday, September 11, 2021 | 7:40 PM EST | Citi Field in Queens, NY | SNY |
| New York Yankees vs New York Mets | Sunday, September 12, 2021 | 8:08 PM EST | Citi Field in Queens, NY | SNY |
| New York Yankees vs Baltimore Orioles | Tuesday, September 14, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Wednesday, September 15, 2021 | 7:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| New York Yankees vs Baltimore Orioles | Thursday, September 16, 2021 | 5:05 PM EST | Oriole Park in Baltimore, MD | MASN/MASN2 |
| Cleveland Indians vs New York Yankees | Friday, September 17, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Cleveland Indians vs New York Yankees | Saturday, September 18, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Cleveland Indians vs New York Yankees | Sunday, September 19, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Texas Rangers vs New York Yankees | Monday, September 20, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Texas Rangers vs New York Yankees | Tuesday, September 21, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Texas Rangers vs New York Yankees | Wednesday, September 22, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| New York Yankees vs Boston Red Sox | Friday, September 24, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Saturday, September 25, 2021 | 4:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Boston Red Sox | Sunday, September 26, 2021 | 7:10 PM EST | Fenway Park in Boston, MA | NESN |
| New York Yankees vs Toronto Blue Jays | Tuesday, September 28, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Wednesday, September 29, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| New York Yankees vs Toronto Blue Jays | Thursday, September 30, 2021 | 7:07 PM EST | Rogers Centre in Toronto, ON | Sportsnet |
| Tampa Bay Rays vs New York Yankees | Friday, October 1, 2021 | 7:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Saturday, October 2, 2021 | 1:05 PM EST | Yankee Stadium in Bronx, NY | YES |
| Tampa Bay Rays vs New York Yankees | Sunday, October 3, 2021 | 3:05 PM EST | Yankee Stadium in Bronx, NY | YES |
