|
| Pittsburgh Pirates vs Chicago Cubs | Thursday, April 1, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Saturday, April 3, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Sunday, April 4, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Cincinnati Reds | Monday, April 5, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Tuesday, April 6, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Wednesday, April 7, 2021 | 12:35 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Chicago Cubs vs Pittsburgh Pirates | Thursday, April 8, 2021 | 1:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Saturday, April 10, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Sunday, April 11, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Monday, April 12, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Tuesday, April 13, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Wednesday, April 14, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Thursday, April 15, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Milwaukee Brewers | Friday, April 16, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Saturday, April 17, 2021 | 7:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Sunday, April 18, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Detroit Tigers | Tuesday, April 20, 2021 | 6:40 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Pittsburgh Pirates vs Detroit Tigers | Wednesday, April 21, 2021 | 6:40 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Pittsburgh Pirates vs Detroit Tigers | Thursday, April 22, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Pittsburgh Pirates vs Minnesota Twins | Friday, April 23, 2021 | 8:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Pittsburgh Pirates vs Minnesota Twins | Saturday, April 24, 2021 | 2:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Pittsburgh Pirates vs Minnesota Twins | Sunday, April 25, 2021 | 2:10 PM EST | Target Field in Minneapolis, MN | Bally Sports North |
| Kansas City Royals vs Pittsburgh Pirates | Tuesday, April 27, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Kansas City Royals vs Pittsburgh Pirates | Wednesday, April 28, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Friday, April 30, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Saturday, May 1, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Sunday, May 2, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs San Diego Padres | Monday, May 3, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs San Diego Padres | Tuesday, May 4, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs San Diego Padres | Wednesday, May 5, 2021 | 8:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs Chicago Cubs | Friday, May 7, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Saturday, May 8, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Sunday, May 9, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Cincinnati Reds vs Pittsburgh Pirates | Monday, May 10, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Tuesday, May 11, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Wednesday, May 12, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Francisco Giants vs Pittsburgh Pirates | Thursday, May 13, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Francisco Giants vs Pittsburgh Pirates | Friday, May 14, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Francisco Giants vs Pittsburgh Pirates | Saturday, May 15, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Francisco Giants vs Pittsburgh Pirates | Sunday, May 16, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs St. Louis Cardinals | Tuesday, May 18, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Wednesday, May 19, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs Atlanta Braves | Thursday, May 20, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| Pittsburgh Pirates vs Atlanta Braves | Friday, May 21, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| Pittsburgh Pirates vs Atlanta Braves | Saturday, May 22, 2021 | 4:10 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| Pittsburgh Pirates vs Atlanta Braves | Sunday, May 23, 2021 | 1:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| Chicago Cubs vs Pittsburgh Pirates | Tuesday, May 25, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Wednesday, May 26, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Thursday, May 27, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Colorado Rockies vs Pittsburgh Pirates | Friday, May 28, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Colorado Rockies vs Pittsburgh Pirates | Saturday, May 29, 2021 | 4:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Colorado Rockies vs Pittsburgh Pirates | Sunday, May 30, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Kansas City Royals | Monday, May 31, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Pittsburgh Pirates vs Kansas City Royals | Tuesday, June 1, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Miami Marlins vs Pittsburgh Pirates | Thursday, June 3, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Miami Marlins vs Pittsburgh Pirates | Friday, June 4, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Miami Marlins vs Pittsburgh Pirates | Saturday, June 5, 2021 | 4:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Miami Marlins vs Pittsburgh Pirates | Sunday, June 6, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Los Angeles Dodgers vs Pittsburgh Pirates | Tuesday, June 8, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Los Angeles Dodgers vs Pittsburgh Pirates | Wednesday, June 9, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Los Angeles Dodgers vs Pittsburgh Pirates | Thursday, June 10, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Milwaukee Brewers | Friday, June 11, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Saturday, June 12, 2021 | 4:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Sunday, June 13, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Washington Nationals | Monday, June 14, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| Pittsburgh Pirates vs Washington Nationals | Tuesday, June 15, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| Pittsburgh Pirates vs Washington Nationals | Wednesday, June 16, 2021 | 4:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| Cleveland Indians vs Pittsburgh Pirates | Friday, June 18, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cleveland Indians vs Pittsburgh Pirates | Saturday, June 19, 2021 | 4:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cleveland Indians vs Pittsburgh Pirates | Sunday, June 20, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago White Sox vs Pittsburgh Pirates | Tuesday, June 22, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago White Sox vs Pittsburgh Pirates | Wednesday, June 23, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs St. Louis Cardinals | Thursday, June 24, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Friday, June 25, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Saturday, June 26, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Sunday, June 27, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs Colorado Rockies | Monday, June 28, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Pittsburgh Pirates vs Colorado Rockies | Tuesday, June 29, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Pittsburgh Pirates vs Colorado Rockies | Wednesday, June 30, 2021 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Milwaukee Brewers vs Pittsburgh Pirates | Thursday, July 1, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Friday, July 2, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Saturday, July 3, 2021 | 4:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Sunday, July 4, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Atlanta Braves vs Pittsburgh Pirates | Monday, July 5, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Atlanta Braves vs Pittsburgh Pirates | Tuesday, July 6, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Atlanta Braves vs Pittsburgh Pirates | Wednesday, July 7, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs New York Mets | Thursday, July 8, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| Pittsburgh Pirates vs New York Mets | Friday, July 9, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| Pittsburgh Pirates vs New York Mets | Saturday, July 10, 2021 | 4:10 PM EST | Citi Field in Queens, NY | SNY |
| Pittsburgh Pirates vs New York Mets | Sunday, July 11, 2021 | 1:10 PM EST | Citi Field in Queens, NY | SNY |
| New York Mets vs Pittsburgh Pirates | Friday, July 16, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| New York Mets vs Pittsburgh Pirates | Saturday, July 17, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| New York Mets vs Pittsburgh Pirates | Sunday, July 18, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Arizona Diamondbacks | Monday, July 19, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| Pittsburgh Pirates vs Arizona Diamondbacks | Tuesday, July 20, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| Pittsburgh Pirates vs Arizona Diamondbacks | Wednesday, July 21, 2021 | 3:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| Pittsburgh Pirates vs San Francisco Giants | Friday, July 23, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| Pittsburgh Pirates vs San Francisco Giants | Saturday, July 24, 2021 | 9:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| Pittsburgh Pirates vs San Francisco Giants | Sunday, July 25, 2021 | 4:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| Milwaukee Brewers vs Pittsburgh Pirates | Tuesday, July 27, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Wednesday, July 28, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Thursday, July 29, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Philadelphia Phillies vs Pittsburgh Pirates | Friday, July 30, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Philadelphia Phillies vs Pittsburgh Pirates | Saturday, July 31, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Philadelphia Phillies vs Pittsburgh Pirates | Sunday, August 1, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Milwaukee Brewers | Monday, August 2, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Tuesday, August 3, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Milwaukee Brewers | Wednesday, August 4, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Pittsburgh Pirates vs Cincinnati Reds | Thursday, August 5, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Friday, August 6, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Saturday, August 7, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Sunday, August 8, 2021 | 1:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Pittsburgh Pirates | Tuesday, August 10, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Wednesday, August 11, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Thursday, August 12, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Friday, August 13, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Saturday, August 14, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Milwaukee Brewers vs Pittsburgh Pirates | Sunday, August 15, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Los Angeles Dodgers | Monday, August 16, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| Pittsburgh Pirates vs Los Angeles Dodgers | Tuesday, August 17, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| Pittsburgh Pirates vs Los Angeles Dodgers | Wednesday, August 18, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| Pittsburgh Pirates vs St. Louis Cardinals | Friday, August 20, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Saturday, August 21, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Sunday, August 22, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Arizona Diamondbacks vs Pittsburgh Pirates | Monday, August 23, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Arizona Diamondbacks vs Pittsburgh Pirates | Tuesday, August 24, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Arizona Diamondbacks vs Pittsburgh Pirates | Wednesday, August 25, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Thursday, August 26, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Friday, August 27, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Saturday, August 28, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Sunday, August 29, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Chicago White Sox | Tuesday, August 31, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Pittsburgh Pirates vs Chicago White Sox | Wednesday, September 1, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| Pittsburgh Pirates vs Chicago Cubs | Thursday, September 2, 2021 | 8:05 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Friday, September 3, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Saturday, September 4, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Pittsburgh Pirates vs Chicago Cubs | Sunday, September 5, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Detroit Tigers vs Pittsburgh Pirates | Monday, September 6, 2021 | 1:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Detroit Tigers vs Pittsburgh Pirates | Tuesday, September 7, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Detroit Tigers vs Pittsburgh Pirates | Wednesday, September 8, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Washington Nationals vs Pittsburgh Pirates | Friday, September 10, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Washington Nationals vs Pittsburgh Pirates | Saturday, September 11, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Washington Nationals vs Pittsburgh Pirates | Sunday, September 12, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Tuesday, September 14, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Wednesday, September 15, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Thursday, September 16, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Pittsburgh Pirates vs Miami Marlins | Friday, September 17, 2021 | 7:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Pittsburgh Pirates vs Miami Marlins | Saturday, September 18, 2021 | 6:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Pittsburgh Pirates vs Miami Marlins | Sunday, September 19, 2021 | 1:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Pittsburgh Pirates vs Cincinnati Reds | Monday, September 20, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Tuesday, September 21, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Cincinnati Reds | Wednesday, September 22, 2021 | 12:35 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| Pittsburgh Pirates vs Philadelphia Phillies | Thursday, September 23, 2021 | 7:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| Pittsburgh Pirates vs Philadelphia Phillies | Friday, September 24, 2021 | 7:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| Pittsburgh Pirates vs Philadelphia Phillies | Saturday, September 25, 2021 | 4:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| Pittsburgh Pirates vs Philadelphia Phillies | Sunday, September 26, 2021 | 1:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| Chicago Cubs vs Pittsburgh Pirates | Tuesday, September 28, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Wednesday, September 29, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Chicago Cubs vs Pittsburgh Pirates | Thursday, September 30, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Friday, October 1, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Saturday, October 2, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Cincinnati Reds vs Pittsburgh Pirates | Sunday, October 3, 2021 | 3:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
