|
| Arizona Diamondbacks vs San Diego Padres | Thursday, April 1, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Friday, April 2, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Saturday, April 3, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Sunday, April 4, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Monday, April 5, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Tuesday, April 6, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Wednesday, April 7, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Texas Rangers | Friday, April 9, 2021 | 8:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| San Diego Padres vs Texas Rangers | Saturday, April 10, 2021 | 7:05 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| San Diego Padres vs Texas Rangers | Sunday, April 11, 2021 | 2:35 PM EST | Globe Life Field in Arlington, TX | Bally Sports Southwest |
| San Diego Padres vs Pittsburgh Pirates | Monday, April 12, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Tuesday, April 13, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Wednesday, April 14, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| San Diego Padres vs Pittsburgh Pirates | Thursday, April 15, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| Los Angeles Dodgers vs San Diego Padres | Friday, April 16, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Saturday, April 17, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Sunday, April 18, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Milwaukee Brewers vs San Diego Padres | Monday, April 19, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Milwaukee Brewers vs San Diego Padres | Tuesday, April 20, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Milwaukee Brewers vs San Diego Padres | Wednesday, April 21, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Los Angeles Dodgers | Thursday, April 22, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Friday, April 23, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Saturday, April 24, 2021 | 9:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Sunday, April 25, 2021 | 7:08 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Arizona Diamondbacks | Tuesday, April 27, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Wednesday, April 28, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Francisco Giants vs San Diego Padres | Friday, April 30, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Saturday, May 1, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Sunday, May 2, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs San Diego Padres | Monday, May 3, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs San Diego Padres | Tuesday, May 4, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs San Diego Padres | Wednesday, May 5, 2021 | 8:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs San Francisco Giants | Friday, May 7, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Saturday, May 8, 2021 | 4:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Sunday, May 9, 2021 | 4:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs Colorado Rockies | Monday, May 10, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Tuesday, May 11, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Wednesday, May 12, 2021 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| St. Louis Cardinals vs San Diego Padres | Friday, May 14, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| St. Louis Cardinals vs San Diego Padres | Saturday, May 15, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| St. Louis Cardinals vs San Diego Padres | Sunday, May 16, 2021 | 7:08 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Monday, May 17, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Tuesday, May 18, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Wednesday, May 19, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Seattle Mariners vs San Diego Padres | Friday, May 21, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Seattle Mariners vs San Diego Padres | Saturday, May 22, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Seattle Mariners vs San Diego Padres | Sunday, May 23, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Milwaukee Brewers | Monday, May 24, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| San Diego Padres vs Milwaukee Brewers | Tuesday, May 25, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| San Diego Padres vs Milwaukee Brewers | Wednesday, May 26, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| San Diego Padres vs Milwaukee Brewers | Thursday, May 27, 2021 | 1:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| San Diego Padres vs Houston Astros | Friday, May 28, 2021 | 8:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| San Diego Padres vs Houston Astros | Saturday, May 29, 2021 | 4:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| San Diego Padres vs Houston Astros | Sunday, May 30, 2021 | 2:10 PM EST | Minute Maid Park in Houston, TX | AT&T SportsNet Southwest |
| San Diego Padres vs Chicago Cubs | Monday, May 31, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| San Diego Padres vs Chicago Cubs | Tuesday, June 1, 2021 | 8:05 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| San Diego Padres vs Chicago Cubs | Wednesday, June 2, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| New York Mets vs San Diego Padres | Thursday, June 3, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| New York Mets vs San Diego Padres | Friday, June 4, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| New York Mets vs San Diego Padres | Saturday, June 5, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| New York Mets vs San Diego Padres | Sunday, June 6, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Chicago Cubs vs San Diego Padres | Monday, June 7, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Chicago Cubs vs San Diego Padres | Tuesday, June 8, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Chicago Cubs vs San Diego Padres | Wednesday, June 9, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs New York Mets | Friday, June 11, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| San Diego Padres vs New York Mets | Saturday, June 12, 2021 | 4:10 PM EST | Citi Field in Queens, NY | SNY |
| San Diego Padres vs New York Mets | Sunday, June 13, 2021 | 1:10 PM EST | Citi Field in Queens, NY | SNY |
| San Diego Padres vs Colorado Rockies | Monday, June 14, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Tuesday, June 15, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Wednesday, June 16, 2021 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Cincinnati Reds vs San Diego Padres | Thursday, June 17, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Cincinnati Reds vs San Diego Padres | Friday, June 18, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Cincinnati Reds vs San Diego Padres | Saturday, June 19, 2021 | 7:15 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Cincinnati Reds vs San Diego Padres | Sunday, June 20, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Monday, June 21, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Tuesday, June 22, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Wednesday, June 23, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Friday, June 25, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Saturday, June 26, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Sunday, June 27, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Cincinnati Reds | Tuesday, June 29, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| San Diego Padres vs Cincinnati Reds | Wednesday, June 30, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| San Diego Padres vs Cincinnati Reds | Thursday, July 1, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| San Diego Padres vs Philadelphia Phillies | Friday, July 2, 2021 | 6:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| San Diego Padres vs Philadelphia Phillies | Saturday, July 3, 2021 | 4:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| San Diego Padres vs Philadelphia Phillies | Sunday, July 4, 2021 | 1:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| Washington Nationals vs San Diego Padres | Monday, July 5, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Washington Nationals vs San Diego Padres | Tuesday, July 6, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Washington Nationals vs San Diego Padres | Wednesday, July 7, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Washington Nationals vs San Diego Padres | Thursday, July 8, 2021 | 9:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Friday, July 9, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Saturday, July 10, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Sunday, July 11, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Washington Nationals | Friday, July 16, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| San Diego Padres vs Washington Nationals | Saturday, July 17, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| San Diego Padres vs Washington Nationals | Sunday, July 18, 2021 | 1:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| San Diego Padres vs Atlanta Braves | Monday, July 19, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| San Diego Padres vs Atlanta Braves | Tuesday, July 20, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| San Diego Padres vs Atlanta Braves | Wednesday, July 21, 2021 | 12:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| San Diego Padres vs Miami Marlins | Thursday, July 22, 2021 | 7:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| San Diego Padres vs Miami Marlins | Friday, July 23, 2021 | 7:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| San Diego Padres vs Miami Marlins | Saturday, July 24, 2021 | 6:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| San Diego Padres vs Miami Marlins | Sunday, July 25, 2021 | 1:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Oakland Athletics vs San Diego Padres | Tuesday, July 27, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Oakland Athletics vs San Diego Padres | Wednesday, July 28, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Thursday, July 29, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Friday, July 30, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Saturday, July 31, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Colorado Rockies vs San Diego Padres | Sunday, August 1, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Oakland Athletics | Tuesday, August 3, 2021 | 9:40 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| San Diego Padres vs Oakland Athletics | Wednesday, August 4, 2021 | 3:37 PM EST | RingCentral Coliseum in Oakland, CA | NBC Sports California |
| Arizona Diamondbacks vs San Diego Padres | Friday, August 6, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Saturday, August 7, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Arizona Diamondbacks vs San Diego Padres | Sunday, August 8, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Miami Marlins vs San Diego Padres | Monday, August 9, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Miami Marlins vs San Diego Padres | Tuesday, August 10, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Miami Marlins vs San Diego Padres | Wednesday, August 11, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Arizona Diamondbacks | Thursday, August 12, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Friday, August 13, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Saturday, August 14, 2021 | 8:10 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Sunday, August 15, 2021 | 4:10 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Colorado Rockies | Monday, August 16, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Tuesday, August 17, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| San Diego Padres vs Colorado Rockies | Wednesday, August 18, 2021 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| Philadelphia Phillies vs San Diego Padres | Friday, August 20, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Philadelphia Phillies vs San Diego Padres | Saturday, August 21, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Philadelphia Phillies vs San Diego Padres | Sunday, August 22, 2021 | 3:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Tuesday, August 24, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Wednesday, August 25, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Dodgers vs San Diego Padres | Thursday, August 26, 2021 | 9:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Los Angeles Angels | Friday, August 27, 2021 | 9:38 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| San Diego Padres vs Los Angeles Angels | Saturday, August 28, 2021 | 9:07 PM EST | Angel Stadium in Anaheim, CA | Bally Sports West |
| San Diego Padres vs Arizona Diamondbacks | Monday, August 30, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Tuesday, August 31, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| San Diego Padres vs Arizona Diamondbacks | Wednesday, September 1, 2021 | 3:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| Houston Astros vs San Diego Padres | Friday, September 3, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Houston Astros vs San Diego Padres | Saturday, September 4, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Houston Astros vs San Diego Padres | Sunday, September 5, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Angels vs San Diego Padres | Tuesday, September 7, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Los Angeles Angels vs San Diego Padres | Wednesday, September 8, 2021 | 8:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Los Angeles Dodgers | Friday, September 10, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Saturday, September 11, 2021 | 9:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Sunday, September 12, 2021 | 4:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs San Francisco Giants | Monday, September 13, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Tuesday, September 14, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Wednesday, September 15, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Thursday, September 16, 2021 | 3:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs St. Louis Cardinals | Friday, September 17, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Diego Padres vs St. Louis Cardinals | Saturday, September 18, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Diego Padres vs St. Louis Cardinals | Sunday, September 19, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Francisco Giants vs San Diego Padres | Tuesday, September 21, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Wednesday, September 22, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Francisco Giants vs San Diego Padres | Thursday, September 23, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Atlanta Braves vs San Diego Padres | Friday, September 24, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Atlanta Braves vs San Diego Padres | Saturday, September 25, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Atlanta Braves vs San Diego Padres | Sunday, September 26, 2021 | 4:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| San Diego Padres vs Los Angeles Dodgers | Tuesday, September 28, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Wednesday, September 29, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs Los Angeles Dodgers | Thursday, September 30, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| San Diego Padres vs San Francisco Giants | Friday, October 1, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Saturday, October 2, 2021 | 4:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| San Diego Padres vs San Francisco Giants | Sunday, October 3, 2021 | 3:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
