| San Francisco 49ers vs Detroit Lions |
Sunday, September 12, 2021 |
1:00 PM EST |
Ford Field in Detroit, MI |
FOX |
| San Francisco 49ers vs Philadelphia Eagles |
Sunday, September 19, 2021 |
1:00 PM EST |
Lincoln Financial Field in Philadelphia, PA |
FOX |
| Green Bay Packers vs San Francisco 49ers |
Sunday, September 26, 2021 |
8:20 PM EST |
Levi’s Stadium in Santa Clara, CA |
NBC |
| Seattle Seahawks vs San Francisco 49ers |
Sunday, October 3, 2021 |
4:05 PM EST |
Levi’s Stadium in Santa Clara, CA |
FOX |
| San Francisco 49ers vs Arizona Cardinals |
Sunday, October 10, 2021 |
4:25 PM EST |
State Farm Stadium in Glendale, AZ |
FOX |
| Indianapolis Colts vs San Francisco 49ers |
Sunday, October 24, 2021 |
8:20 PM EST |
Levi’s Stadium in Santa Clara, CA |
NBC |
| San Francisco 49ers vs Chicago Bears |
Sunday, October 31, 2021 |
1:00 PM EST |
Soldier Field in Chicago, IL |
FOX |
| Arizona Cardinals vs San Francisco 49ers |
Sunday, November 7, 2021 |
4:25 PM EST |
Levi’s Stadium in Santa Clara, CA |
FOX |
| Los Angeles Rams vs San Francisco 49ers |
Monday, November 15, 2021 |
8:15 PM EST |
Levi’s Stadium in Santa Clara, CA |
ESPN |
| San Francisco 49ers vs Jacksonville Jaguars |
Sunday, November 21, 2021 |
1:00 PM EST |
TIAA Bank Field in Jacksonville, FL |
FOX |
| Minnesota Vikings vs San Francisco 49ers |
Sunday, November 28, 2021 |
4:25 PM EST |
Levi’s Stadium in Santa Clara, CA |
FOX |
| San Francisco 49ers vs Seattle Seahawks |
Sunday, December 5, 2021 |
8:20 PM EST |
Lumen Field in Seattle, WA |
NBC |
| San Francisco 49ers vs Cincinnati Bengals |
Sunday, December 12, 2021 |
1:00 PM EST |
Paul Brown Stadium in Cincinnati, OH |
CBS |
| Atlanta Falcons vs San Francisco 49ers |
Sunday, December 19, 2021 |
4:05 PM EST |
Levi’s Stadium in Santa Clara, CA |
CBS |
| San Francisco 49ers vs Tennessee Titans |
Thursday, December 23, 2021 |
8:20 PM EST |
Nissan Stadium in Nashville, TN |
NFLN |
| Houston Texans vs San Francisco 49ers |
Sunday, January 2, 2022 |
4:05 PM EST |
Levi’s Stadium in Santa Clara, CA |
CBS |
| San Francisco 49ers vs Los Angeles Rams |
Sunday, January 9, 2022 |
4:25 PM EST |
SoFi Stadium in Inglewood, CA |
FOX |
