|
| St. Louis Cardinals vs Cincinnati Reds | Thursday, April 1, 2021 | 4:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Saturday, April 3, 2021 | 4:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Sunday, April 4, 2021 | 1:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Miami Marlins | Monday, April 5, 2021 | 6:40 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| St. Louis Cardinals vs Miami Marlins | Tuesday, April 6, 2021 | 6:40 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| St. Louis Cardinals vs Miami Marlins | Wednesday, April 7, 2021 | 4:10 PM EST | Marlins Park in Miami, FL | Bally Sports Florida |
| Milwaukee Brewers vs St. Louis Cardinals | Thursday, April 8, 2021 | 4:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Saturday, April 10, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Sunday, April 11, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Washington Nationals vs St. Louis Cardinals | Monday, April 12, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Washington Nationals vs St. Louis Cardinals | Tuesday, April 13, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Washington Nationals vs St. Louis Cardinals | Wednesday, April 14, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Philadelphia Phillies | Friday, April 16, 2021 | 7:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| St. Louis Cardinals vs Philadelphia Phillies | Saturday, April 17, 2021 | 4:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| St. Louis Cardinals vs Philadelphia Phillies | Sunday, April 18, 2021 | 1:05 PM EST | Citizens Bank Park in Philadelphia, PA | NBC Sports Philadelphia |
| St. Louis Cardinals vs Washington Nationals | Monday, April 19, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| St. Louis Cardinals vs Washington Nationals | Tuesday, April 20, 2021 | 7:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| St. Louis Cardinals vs Washington Nationals | Wednesday, April 21, 2021 | 4:05 PM EST | Nationals Park in Washington, D.C. | MASN/MASN2 |
| Cincinnati Reds vs St. Louis Cardinals | Friday, April 23, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Saturday, April 24, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Sunday, April 25, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Philadelphia Phillies vs St. Louis Cardinals | Monday, April 26, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Philadelphia Phillies vs St. Louis Cardinals | Tuesday, April 27, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Philadelphia Phillies vs St. Louis Cardinals | Wednesday, April 28, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Philadelphia Phillies vs St. Louis Cardinals | Thursday, April 29, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Pittsburgh Pirates | Friday, April 30, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Saturday, May 1, 2021 | 6:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Sunday, May 2, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| New York Mets vs St. Louis Cardinals | Monday, May 3, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| New York Mets vs St. Louis Cardinals | Tuesday, May 4, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| New York Mets vs St. Louis Cardinals | Wednesday, May 5, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| New York Mets vs St. Louis Cardinals | Thursday, May 6, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Colorado Rockies vs St. Louis Cardinals | Friday, May 7, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Colorado Rockies vs St. Louis Cardinals | Saturday, May 8, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Colorado Rockies vs St. Louis Cardinals | Sunday, May 9, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Milwaukee Brewers | Tuesday, May 11, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Wednesday, May 12, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Thursday, May 13, 2021 | 1:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs San Diego Padres | Friday, May 14, 2021 | 10:10 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| St. Louis Cardinals vs San Diego Padres | Saturday, May 15, 2021 | 8:40 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| St. Louis Cardinals vs San Diego Padres | Sunday, May 16, 2021 | 7:08 PM EST | Petco Park in San Diego, CA | Bally Sports San Diego |
| Pittsburgh Pirates vs St. Louis Cardinals | Tuesday, May 18, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Wednesday, May 19, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Friday, May 21, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Saturday, May 22, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Sunday, May 23, 2021 | 7:08 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Chicago White Sox | Monday, May 24, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| St. Louis Cardinals vs Chicago White Sox | Tuesday, May 25, 2021 | 8:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| St. Louis Cardinals vs Chicago White Sox | Wednesday, May 26, 2021 | 2:10 PM EST | Guaranteed Rate Field in Chicago, IL | NBC Sports Chicago |
| St. Louis Cardinals vs Arizona Diamondbacks | Thursday, May 27, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| St. Louis Cardinals vs Arizona Diamondbacks | Friday, May 28, 2021 | 9:40 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| St. Louis Cardinals vs Arizona Diamondbacks | Saturday, May 29, 2021 | 10:10 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| St. Louis Cardinals vs Arizona Diamondbacks | Sunday, May 30, 2021 | 4:10 PM EST | Chase Field in Phoenix, AZ | Bally Sports Arizona |
| St. Louis Cardinals vs Los Angeles Dodgers | Monday, May 31, 2021 | 9:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| St. Louis Cardinals vs Los Angeles Dodgers | Tuesday, June 1, 2021 | 10:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| St. Louis Cardinals vs Los Angeles Dodgers | Wednesday, June 2, 2021 | 9:10 PM EST | Dodger Stadium in Los Angeles, CA | Spectrum Sportsnet LA |
| Cincinnati Reds vs St. Louis Cardinals | Thursday, June 3, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Friday, June 4, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Saturday, June 5, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Sunday, June 6, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cleveland Indians vs St. Louis Cardinals | Tuesday, June 8, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cleveland Indians vs St. Louis Cardinals | Wednesday, June 9, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Chicago Cubs | Friday, June 11, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Saturday, June 12, 2021 | 7:15 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Sunday, June 13, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Miami Marlins vs St. Louis Cardinals | Monday, June 14, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Miami Marlins vs St. Louis Cardinals | Tuesday, June 15, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Miami Marlins vs St. Louis Cardinals | Wednesday, June 16, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Atlanta Braves | Thursday, June 17, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| St. Louis Cardinals vs Atlanta Braves | Friday, June 18, 2021 | 7:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| St. Louis Cardinals vs Atlanta Braves | Saturday, June 19, 2021 | 7:15 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| St. Louis Cardinals vs Atlanta Braves | Sunday, June 20, 2021 | 1:20 PM EST | Truist Park in Cumberland, GA | Bally Sports South |
| St. Louis Cardinals vs Detroit Tigers | Tuesday, June 22, 2021 | 7:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| St. Louis Cardinals vs Detroit Tigers | Wednesday, June 23, 2021 | 1:10 PM EST | Comerica Park in Detroit, MI | Bally Sports Detroit |
| Pittsburgh Pirates vs St. Louis Cardinals | Thursday, June 24, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Friday, June 25, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Saturday, June 26, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Sunday, June 27, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Arizona Diamondbacks vs St. Louis Cardinals | Monday, June 28, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Arizona Diamondbacks vs St. Louis Cardinals | Tuesday, June 29, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Arizona Diamondbacks vs St. Louis Cardinals | Wednesday, June 30, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Colorado Rockies | Thursday, July 1, 2021 | 8:40 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| St. Louis Cardinals vs Colorado Rockies | Friday, July 2, 2021 | 8:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| St. Louis Cardinals vs Colorado Rockies | Saturday, July 3, 2021 | 9:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| St. Louis Cardinals vs Colorado Rockies | Sunday, July 4, 2021 | 3:10 PM EST | Coors Field in Denver, CO | AT&T SportsNet Rocky Mountain |
| St. Louis Cardinals vs San Francisco Giants | Monday, July 5, 2021 | 5:05 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| St. Louis Cardinals vs San Francisco Giants | Tuesday, July 6, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| St. Louis Cardinals vs San Francisco Giants | Wednesday, July 7, 2021 | 9:45 PM EST | Oracle Park in San Francisco, CA | NBC Sports Bay Area |
| St. Louis Cardinals vs Chicago Cubs | Friday, July 9, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Saturday, July 10, 2021 | 7:15 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Sunday, July 11, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| San Francisco Giants vs St. Louis Cardinals | Friday, July 16, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Francisco Giants vs St. Louis Cardinals | Saturday, July 17, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Francisco Giants vs St. Louis Cardinals | Sunday, July 18, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Monday, July 19, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Tuesday, July 20, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Wednesday, July 21, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Thursday, July 22, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Cincinnati Reds | Friday, July 23, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Saturday, July 24, 2021 | 7:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Sunday, July 25, 2021 | 1:10 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cleveland Indians | Tuesday, July 27, 2021 | 7:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| St. Louis Cardinals vs Cleveland Indians | Wednesday, July 28, 2021 | 1:10 PM EST | Progressive Field in Cleveland, OH | SportsTime Ohio |
| Minnesota Twins vs St. Louis Cardinals | Friday, July 30, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Minnesota Twins vs St. Louis Cardinals | Saturday, July 31, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Minnesota Twins vs St. Louis Cardinals | Sunday, August 1, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Atlanta Braves vs St. Louis Cardinals | Tuesday, August 3, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Atlanta Braves vs St. Louis Cardinals | Wednesday, August 4, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Atlanta Braves vs St. Louis Cardinals | Thursday, August 5, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Kansas City Royals vs St. Louis Cardinals | Friday, August 6, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Kansas City Royals vs St. Louis Cardinals | Saturday, August 7, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Kansas City Royals vs St. Louis Cardinals | Sunday, August 8, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Pittsburgh Pirates | Tuesday, August 10, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Wednesday, August 11, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Thursday, August 12, 2021 | 12:35 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Kansas City Royals | Friday, August 13, 2021 | 8:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| St. Louis Cardinals vs Kansas City Royals | Saturday, August 14, 2021 | 7:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| St. Louis Cardinals vs Kansas City Royals | Sunday, August 15, 2021 | 2:10 PM EST | Kauffman Stadium in Kansas City, MO | Bally Sports Kansas City |
| Milwaukee Brewers vs St. Louis Cardinals | Tuesday, August 17, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Wednesday, August 18, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Thursday, August 19, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Friday, August 20, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Saturday, August 21, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Pittsburgh Pirates vs St. Louis Cardinals | Sunday, August 22, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Detroit Tigers vs St. Louis Cardinals | Tuesday, August 24, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Detroit Tigers vs St. Louis Cardinals | Wednesday, August 25, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Pittsburgh Pirates | Thursday, August 26, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Friday, August 27, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Saturday, August 28, 2021 | 7:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Pittsburgh Pirates | Sunday, August 29, 2021 | 1:05 PM EST | PNC Park in Pittsburgh, PA | AT&T SportsNet Pittsburgh |
| St. Louis Cardinals vs Cincinnati Reds | Monday, August 30, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Tuesday, August 31, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Cincinnati Reds | Wednesday, September 1, 2021 | 6:40 PM EST | Great American Ball Park in Cincinnati, OH | Bally Sports Ohio |
| St. Louis Cardinals vs Milwaukee Brewers | Friday, September 3, 2021 | 8:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Saturday, September 4, 2021 | 7:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Sunday, September 5, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| Los Angeles Dodgers vs St. Louis Cardinals | Monday, September 6, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Los Angeles Dodgers vs St. Louis Cardinals | Tuesday, September 7, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Los Angeles Dodgers vs St. Louis Cardinals | Wednesday, September 8, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Los Angeles Dodgers vs St. Louis Cardinals | Thursday, September 9, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Friday, September 10, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Saturday, September 11, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Cincinnati Reds vs St. Louis Cardinals | Sunday, September 12, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs New York Mets | Monday, September 13, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| St. Louis Cardinals vs New York Mets | Tuesday, September 14, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| St. Louis Cardinals vs New York Mets | Wednesday, September 15, 2021 | 7:10 PM EST | Citi Field in Queens, NY | SNY |
| San Diego Padres vs St. Louis Cardinals | Friday, September 17, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Diego Padres vs St. Louis Cardinals | Saturday, September 18, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| San Diego Padres vs St. Louis Cardinals | Sunday, September 19, 2021 | 2:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| St. Louis Cardinals vs Milwaukee Brewers | Monday, September 20, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Tuesday, September 21, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Wednesday, September 22, 2021 | 7:40 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Milwaukee Brewers | Thursday, September 23, 2021 | 2:10 PM EST | American Family Field in Milwaukee, WI | Bally Sports Wisconsin |
| St. Louis Cardinals vs Chicago Cubs | Friday, September 24, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Saturday, September 25, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| St. Louis Cardinals vs Chicago Cubs | Sunday, September 26, 2021 | 2:20 PM EST | Wrigley Field in Chicago, IL | Marquee Sports Network |
| Milwaukee Brewers vs St. Louis Cardinals | Tuesday, September 28, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Wednesday, September 29, 2021 | 7:45 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Milwaukee Brewers vs St. Louis Cardinals | Thursday, September 30, 2021 | 1:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Friday, October 1, 2021 | 8:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Saturday, October 2, 2021 | 7:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
| Chicago Cubs vs St. Louis Cardinals | Sunday, October 3, 2021 | 3:15 PM EST | Busch Stadium in St. Louis, MO | Bally Sports Midwest |
